Sökning: "Avdelningen för klinisk genetik"

Visar resultat 1 - 5 av 91 avhandlingar innehållade orden Avdelningen för klinisk genetik.

  1. 1. Seminal Influence on the Oviduct : Mating and/or semen components induce gene expression changes in the pre-ovulatory functional sperm reservoir in poultry and pigs

    Författare :Mohammad Atikuzzaman; Heriberto Rodriguez-Martinez; Dominic Wright; Karl-Eric Magnusson; Maria Jenmalm; Matthias Laska; Patrice Humblot; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Seminal plasma; proteome peptidome; oviduct; gene expression; chicken; pig;

    Sammanfattning : Internal fertilization occurs in birds and eutherian mammals. Foetal development, however, is either extra- respectively intra-corpore (egg vs uterus). LÄS MER

  3. 2. Unwinding the layers of high hyperdiploid childhood acute lymphoblastic leukemia

    Författare :Larissa Helena Moura-Castro; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; acute lymphoblastic leukaemia ALL ; high hyperdiploid ALL; chromatin structure; transcriptional regulation; CTCF; cohesin; clonal heterogeneity;

    Sammanfattning : .... LÄS MER

  4. 3. MOLECULAR PROFILING OF UROTHELIAL CARCINOMA

    Författare :David Lindgren; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytogenetik; Urology; nephrology; Urologi; nefrologi; Clinical genetics; Klinisk genetik; cytogenetics; Genetics; cancer; onkologi; Cytologi; cancerology; oncology; Cytology; TP53; FGFR3; gene expression profiling; microarray; bladder cancer; urothelial carcinoma; Genetik;

    Sammanfattning : The general aim of this thesis was to molecularly characterize urothelial carcinoma (UC) at the transcriptional level using gene expression microarrays to improve the classification and pathogenetic understanding of this disease. In the first two studies (Articles I and II), gene expression profiling was used to study dysregulated transcriptional networks in a large cohort of UCs. LÄS MER

  5. 4. Genetic Characterization of Bone and Soft Tissue Tumors

    Författare :Anna Dahlen; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical genetics; Klinisk genetik; cytogenetik; Genetik; cytogenetics; mesenchymal tumor; pericytoma; Genetics; chondroma; lipoma;

    Sammanfattning : Bone and soft tissue tumors (BSTT) constitute a heterogeneous group of neoplasms of mesenchymal and neuroectodermal origin. Although many BSTT are rare, it has become clear that BSTT are characterized by recurrent acquired chromosomal aberrations, and the general aim of this thesis have been to apply molecular genetic and molecular cytogenetic techniques to further characterize recurrent breakpoints and deletions, and to search for candidate target genes. LÄS MER

  7. 5. Trisomies in Hematologic Malignancies

    Författare :Kajsa Paulsson; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical genetics; Klinisk genetik; cytogenetik; Genetik; cytogenetics; Genetics; leukemia; chromosome aberration; trisomy;

    Sammanfattning : Acquired clonal chromosome aberrations, closely associated with leukemogenesis, are found in many hematologic malignancies. Although the balanced rearrangements, such as translocations and inversions, are the ones most commonly thought of in the context of leukemias, gains of chromosomes ? e.g.. LÄS MER