Sökning: "brain blood"

Visar resultat 6 - 10 av 650 avhandlingar innehållade orden brain blood.

  1. 6. Stereoselective Transport of Drugs Across the Blood-Brain Barrier (BBB) In Vivo and In Vitro : Pharmacokinetic and Pharmacodynamic Studies of the (S)- and (R)-Enantiomers of Different 5-HT1A Receptor Agonists and Antagonists

    Författare :Hongmei Yan; Lennart Paalzow; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; pindolol; propranolol; 2- di-n-propylamino tetralin; racemate; enantiomer; drug distribution; brain; rat; blood-brain barrier; Neurovetenskap; Neurology; Neurologi; Psychiatry; psykiatri;

    Sammanfattning : Delivery of drugs to the brain requires passage across the blood-brain barrier (BBB). Both for drugs already on the market and for new drugs under development, it is important to know to what extent a drug enters the CNS. Many drugs used clinically are racemic mixtures, i.e. LÄS MER

  3. 7. Quantitative Aspects of Nanodelivery Across the Blood-Brain Barrier : Exemplified with the Opioid Peptide DAMGO

    Författare :Annika Lindqvist; Margareta Hammarlund-Udenaes; Markus Fridén; William Elmquist; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; blood-brain barrier; liposomes; nanocarriers; brain delivery; pharmacokinetics; modeling and simulation; microdialysis; opioid peptide; DAMGO; LC-MS MS; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : The use of nanocarriers is an intriguing approach in the development of efficacious treatment for brain disorders. The aim of the conducted research was to evaluate and quantify the impact of a liposomal nanocarrier formulation on the brain drug delivery. LÄS MER

  4. 8. Diving and the brain

    Författare :Anders Rosén; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; biomarkers; brain; central nervous system; decompression sickness; dive research; diving; neuronal damage; saturation diving; tau protein; venous gas embolism; neurofilament light; glial fibrillary acid protein; tau; VGE;

    Sammanfattning : Abstract Introduction There are reports that long-term diving is associated with cognitive impairments. This raises the question if diving itself is harmful to the brain in the absence of decompression sickness or hypoxia. LÄS MER

  5. 9. Effects of Mobile Phone Radiation upon the Mammalian Brain

    Författare :Henrietta Nittby; Sektion IV; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mobile phone; electromagnetic radiation; Blood-brain barrier; brain; rat;

    Sammanfattning : oday about half of the world's population owns the microwave producing mobile phones. The blood-brain barrier (BBB) protects the mammalian brain from potentially harmful substances circulating in the blood. LÄS MER

  7. 10. Brain Tissue Oxygenation in Traumatic Brain Injury : Experimental and Clinical Studies

    Författare :Karlis Purins; Anders Lewén; Per Enblad; Oliver Sakowitz; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Brain tissue oxygenation; Cerebral metabolism; Traumatic brain injury; Cerebral ischemia; Threshold levels; Neurovent-PTO; Microdialysis; Neurosurgery; Neurokirurgi;

    Sammanfattning : Traumatic brain injury (TBI) is a major cause of death and disability. TBI is frequently followed by cerebral ischemia which is a great contributor to secondary brain damage. The main causes of cerebral ischemia are pathophysiological changes in cerebral blood flow and metabolism. LÄS MER