Sökning: "nanocarriers"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet nanocarriers.

1. 1. Quantitative Aspects of Nanodelivery Across the Blood-Brain Barrier : Exemplified with the Opioid Peptide DAMGO

   Författare :Annika Lindqvist; Margareta Hammarlund-Udenaes; Markus Fridén; William Elmquist; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; blood-brain barrier; liposomes; nanocarriers; brain delivery; pharmacokinetics; modeling and simulation; microdialysis; opioid peptide; DAMGO; LC-MS MS; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : The use of nanocarriers is an intriguing approach in the development of efficacious treatment for brain disorders. The aim of the conducted research was to evaluate and quantify the impact of a liposomal nanocarrier formulation on the brain drug delivery. LÄS MER

3. 2. Development and Evaluation of Lipodisks Intended for Use as Biomimetic Membranes and Drug Carriers

   Författare :Malin Morin Zetterberg; Katarina Edwards; Jonas Bergquist; Ana Maria Carmona-Ribeiro; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; model membranes; drug delivery; drug partitioning; antimicrobial peptides; nanocarriers; cryo-TEM; polymer-stabilized bilayer disks; Chemistry with specialization in Physical Chemistry; Kemi med inriktning mot fysikalisk kemi;

   Sammanfattning : Polyethylene glycol-stabilized lipodisks have emerged as a novel type of lipid-based nanoparticles with high potential as both drug carriers and biomimetic membranes. In this thesis we assess both of these applications, and show how the properties of the lipodisks can be further developed and optimized. LÄS MER

4. 3. Effects of gangliosides and PEG-lipids on the structure, properties and interactions of lipid self-assemblies

   Författare :Philipp Grad; Katarina Edwards; Marité Cárdenas; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Lipid self-assemblies; solution-solid interface; liposomes; lipodisks; lipid bilayers; liposome permeability; cuvettes;

   Sammanfattning : When developing or utilizing lipid-based nanocarriers detailed structural characterization of the lipid self-assemblies, as well as in depth knowledge and control of their interaction with solids materials, is necessary to understand the behaviour. Disregarding one of the parameters can lead to misinterpretation of the results due to non-uniform samples or experimental artifacts caused by undesirable interactions with solid surfaces. LÄS MER

5. 4. Development of lipodisks as carriers for cationic amphiphilic peptides

   Författare :Karin Reijmar Brunnström; Katarina Edwards; Fredrik Höök; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : Antibiotics have made a tremendous contribution to mankind. They are one of the most successful medicines in human history. However, more and more bacterial strains develop resistance and the risk to public health can hardly be overstated. New types of antibiotics are urgently needed. LÄS MER

7. 5. Photoluminescence-based characterization of bioengineered nanovesicles and erbium emitters

   Författare :Maryam Sanaee; Katia Gallo; Jerker Widengren; Martin Hof; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Bioengineered nanovesicles; Coincident fluorescent burst analysis; Drug loading; Erbium emitters; Lithium niobate; Photoluminescence.; Bioingenjörskonstruerade nanovesiklar; Analys av sammanfallande fluorescerande blossteknik; Läkemedelslastning; Erbium-emitterare; Lithium niobate; Fotoluminiscens.; Biologisk fysik; Biological Physics; Optics and Photonics; Optik och fotonik;

   Sammanfattning : In recent decades, photoluminescence properties of single molecules and ions have opened new possibilities for studies on smaller size scales, below the light-diffraction limit. In this thesis, the advantages of such single photon emitters were harnessed and studied mainly in the field of biophysics, but also, in investigations within solid state photonics. LÄS MER