Sökning: "Neurology"

Visar resultat 1 - 5 av 340 avhandlingar innehållade ordet Neurology.

  1. 1. Synaptic Integration of Hippocampal Neurons Generated in the Adult Brain: Influence of a Pathological Environment

    Detta är en avhandling från Neurology, Lund

    Författare :Katherine Jakubs; Lunds universitet.; Lund University.; [2007]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurofysiologi; neuropsykologi; Neurologi; synaptic plasticity; GABA; glutamate; GFP; Neurology; neuropsychology; neurophysiology; hippocampus; dentate gyrus; neurogenesis; LPS; inflammation; epilepsy; SE; patch-clamp;

    Sammanfattning : The adult brain constantly produces new neurons from endogenous neural progenitor cells located in at least two regions, the subgranular zone (SGZ) in dentate gyrus of the hippocampus, and the subventricular zone (SVZ). Major efforts are underway to discover the functional significance of new neurons in the adult brain. LÄS MER

  2. 2. Curing Multiple Sclerosis How to do it and how to prove it

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Joachim Burman; Uppsala universitet.; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; biomarkers; cerebrospinal fluid; cytokines; hematopoietic stem cell transplantation; immunology; magnetic resonance imaging; multiple sclerosis; neuroimmunology; neurology; Neurology; Neurologi;

    Sammanfattning : Hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for multiple sclerosis (MS) with now more than 600 documented cases in the medical literature. Long-term remission can be achieved with this therapy, but when is it justified to claim that a patient is cured from MS? In attempt to answer this question, the outcome of the Swedish patients is described, mechanisms behind the therapeutic effect are discussed and new tools for demonstration of absence of disease have been developed. LÄS MER

  3. 3. Experimental Stroke and Neurotrophins: Regulation, function and gene transfer of neurotrophins in rat and mouse models of focal cerebral ischemia

    Detta är en avhandling från Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, 221 84 Lund, Sweden

    Författare :Gunnar Andsberg; Lunds universitet.; Lund University.; [2001]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; neuropsychology; animal behaviour; striatum; stereology; immunohistochemistry; focal cerebral ischemia; nerve growth factors; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : Stroke caused by focal cerebral ischemia is a major cause of death and neurological disability in humans. The forebrain region most commonly affected by ischemic incidents is that supplied by the middle cerebral artery. LÄS MER

  4. 4. Role of Neuropeptides and Neurotrophic Factors in Seizure Modulation

    Detta är en avhandling från Avtandil Nanobashvili, Section of Restorative Neurology, WNC, BMC A11, 221 84 Lund

    Författare :Avtandil Nanobashvili; Lunds universitet.; Lund University.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurophysiology; neuropsychology; brain slice; entorhinal cortex; hippocampus; galanin; glial cell line-derived neurotrophic factor; neuropeptide Y; epilepsy; kindling; Neurology; neurofysiologi; neuropsykologi; Neurologi;

    Sammanfattning : The presented thesis explores role of glial cell line derived neurotrophic factor family receptor a2 (GFRa2), as well as neuropeptide Y (NPY) and galanin and their receptors in modulation of seizure activity. We demonstrate that mice lacking the GFRa2 gene (GFRa2-/-) exhibit suppressed seizure generalization in traditional and rapid kindling models. LÄS MER

  5. 5. Assessment of Graft Effects and Function in Cell Replacement Therapy for Parkinson's Disease

    Detta är en avhandling från Peter Hagell, Restorative Neurology, Wallenberg Neuroscience Center, BMC A11, University Hospital, 221 84 Lund, Sweden

    Författare :Peter Hagell; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurologi; neurophysiology; neuropsykologi; neurofysiologi; neuropsychology; Neurology; measurement; psychometrics; perceived health; dyskinesias; assessment; striatum; positron emission tomography; dopamine; Parkinson s disease; transplantation;

    Sammanfattning : This explorative study aimed to apply, develop, and evaluate assessment methods at various levels in cell replacement therapy for Parkinson’s disease (PD). Observed motor effects in five grafted patients support that timed motor tasks and clinical ratings of parkinsonism are able to monitor motor function, but their psychometric properties need further attention. LÄS MER