Sökning: "Neurotrophic factor"

Visar resultat 16 - 20 av 157 avhandlingar innehållade orden Neurotrophic factor.

1. 16. Neurotrophic signalling by GDNF and its receptors

   Författare :Miles Trupp; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Many investigators have sought a polypeptide which would alleviate the neuronal loss associated with Parkinson's disease--specifically dopaminergic neurons of the ventral mesencephalon. The survival of this population of neurons has been known for some time to be promoted by soluble factors present in the conditioned media of glial cell lines. LÄS MER

3. 17. Neurotrophic and immune regulatory factors in neuroinflammation

   Författare :Alexander W Gielen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Neurotrophins; EAE; MS; TIM; Neuroprotection;

   Sammanfattning : Inflammatory reactions in the nervous system act as a double-edged sword. On the one hand, neuroinflammation can have very devastating effects on the nervous system, leading to neurological dysfunction. LÄS MER

4. 18. Post-Ischemic Housing Conditions Influence On Gene Transcription And Translation After Permanent Focal Brain Ischemia In Rats

   Författare :Li-Ru Zhao; Sektion IV; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rats; brain-derived neurotrophic factor; mRNA; nerve growth factor-induced gene A; corticosteroid receptors; in situ hybridization; Neurologi; neurophysiology; Neurology; neuropsychology; brain ischemia; enriched environment; neuropsykologi; neurofysiologi;

   Sammanfattning : Enriched environment (EE) housing significantly ameliorates neurological deficits induced by cortical brain ischemia without changing infarction size, suggesting that EE-related functional benefits are associated with neuronal plasticity events in the remaining tissue. Brain-derived neurotrophic factor (BDNF), nerve growth factor-induced gene A (NGFI-A) and corticosteroid receptors (mineralocorticoid receptor, MR; glucocorticoid receptor, GR) have been demonstrated to be involved in brain plasticity. LÄS MER

5. 19. Gene therapy in epilepsy: neuropeptides and neurotrophic factors

   Författare :Irene Kanter Schlifke; Lund Wallenberg Neurocentrum; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurologi; neurophysiology; neuropsychology; Neurology; piriform cortex; hippocampus; neuropsykologi; encapsulated cells; viral vectors; GDNF; galanin; epilepsy; gene therapy; neurofysiologi;

   Sammanfattning : Temporal lobe epilepsy (TLE) is the most common form of epilepsy among adult patients, and the most problematic one as seizures cannot be controlled by currently available drugs in 30 % of patients. Gene therapy based on overexpression of endogenous anti-epileptic agents such as the neuropeptide galanin and the glial cell line-derived neurotrophic factor (GDNF) represents a promising new approach for treatment of TLE. LÄS MER

7. 20. New Conditional Gene Targeting Methods : For Studying Neurotrophic Mechanisms in Selected Neuronal Populations

   Författare :Jonas Lindeberg; Christer Betsholtz; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Neurovetenskap; Neurology; Neurologi; Developmental Neurosciences; Medicinsk utvecklings- och neurobiologi;

   Sammanfattning : Powerful techniques to manipulate the mouse genome have had a great impact on our understanding of biology. The major drawback with conventional transgenic methods is that the genetic alteration will be present in every cell of the animal, from conception and onwards. LÄS MER