Sökning: "exposure in vivo"

Visar resultat 1 - 5 av 182 avhandlingar innehållade orden exposure in vivo.

  1. 1. Development of Methods for Assessing Unbound Drug Exposure in the Brain In vivo, in vitro and in silico

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Markus Fridén; Uppsala universitet.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; Drug transport; Tissue distribution; Transporters; Pharmacokinetics; PHARMACY Other pharmacy; FARMACI Övrig farmaci; PHARMACY Biopharmacy; FARMACI Biofarmaci; PHARMACY Pharmaceutical pharmacology; FARMACI Farmaceutisk farmakologi; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

    Sammanfattning : The blood-brain barrier is formed by tightly joined capillary cells with transporter proteins and acts as to regulate the brain concentration of nutrients as well as many drugs. When developing central nervous system drugs it is necessary to measure the unbound drug concentration in the brain, i.e. the unbound brain exposure. LÄS MER

  2. 2. Stuck in mind the role of catastrophizing in pain

    Detta är en avhandling från Örebro : Örebro universitet

    Författare :Ida K. Flink; Örebro universitet.; [2011]
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; catastrophizing; pain; fear avoidance; problem solving; Psychology; Psykologi;

    Sammanfattning : Pain catastrophizing emerges in the literature as one of the most important psychological determinants of both pain itself and the negative outcomes commonly associated with it. However, despite decades of research confirming the impact of catastrophizing, there are still areas that remain unexplored or in which the surface has only been scratched. LÄS MER

  3. 3. Investigation and Prediction of Small Intestinal Precipitation of Poorly Soluble Drugs a Study Involving in silico, in vitro and in vivo Assessment

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Sara Carlert; Uppsala universitet.; [2012]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gastrointestinal precipitation; crystallization; crystal nucleation; crystal growth; classical nucleation theory; poorly soluble drugs; drug absorption; biopharmaceutics classification system; in vitro in vivo correlations IVIVC ; in silico prediction; human intestinal fluid; dog intestinal fluid; simulated intestinal fluid; Biofarmaci; Biopharmaceutics;

    Sammanfattning : The main objectives of the present project were to increase the understanding of small intestinal precipitation of poorly soluble pharmaceutical drugs, investigate occurrence of crystalline small intestinal precipitation and effects of precipitation on absorption. The aim was to create and evaluate methods of predicting crystalline small intestinal drug precipitation using in vivo, in vitro and in silico models. LÄS MER

  4. 4. Tamiflu in the Water Resistance Dynamics of Influenza A Virus in Mallards Exposed to Oseltamivir

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Anna Gillman; Uppsala universitet.; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Influenza A virus; avian influenza; oseltamivir; neuraminidase inhibitors; resistance; environmental; Mallard; waterfowl; Medicinsk vetenskap; Medical Science;

    Sammanfattning : The natural reservoir of influenza A virus (IAV) is wild waterfowl, and all human IAVs have their genetic origins from avian viruses. Neuraminidase inhibitors (NAIs) are currently the best drugs for treatment of human influenza; therefore, the orally available NAI oseltamivir (Tamiflu®) has been stockpiled worldwide as part of pandemic preparedness planning. LÄS MER

  5. 5. Phosphatidylethanol - formation and degradation in blood and organs

    Detta är en avhandling från Steina Aradóttir, Medical neurochemistry, Lund University Hospital, S-221 85 Lund, Sweden

    Författare :Steina Aradottir; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Public health; Diagnostik; Diagnostics; organs; blood; HPLC; in vitro; in vivo; human; rat; phosphatidylethanol; phospholipase D; alcohol; ethanol; epidemiology; Folkhälsa; epidemiologi;

    Sammanfattning : Phosphatidylethanol (PEth) is an abnormal phospholipid formed exclusively by the action of phospholipase D (PLD) in the presence of ethanol. The degradation of PEth is slow and due to its accumulation in some cells the possibility to use PEth as marker of ethanol intake has been proposed. LÄS MER