Sökning: "brain-derived neurotrophic factor"

Visar resultat 1 - 5 av 73 avhandlingar innehållade orden brain-derived neurotrophic factor.

1. 1. Brain-derived neurotrophic factor in cerebral ischemia: a quantitative study on surviving and newly formed neurons

   Författare :Elin Gustafsson; Lund Klinisk fysiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; brain-derived neurotrophic factor; cerebral ischemia; neuronal survival; neurogenesis; hippocampus; striatum; immunocytochemistry; stereology; neuropsykologi; Neurologi; neurophysiology; neuropsychology; neurofysiologi; Neurology;

   Sammanfattning : This study explores the role of brain-derived neurotrophic factor (BDNF) for neuronal vulnerability and neurogenesis following cerebral ischemia in the rat. Cerebral ischemia results in selective neuronal cell loss in specific brain regions. We here demonstrate the rank order of vulnerability in two regions affected by global forebrain ischemia, i. LÄS MER

3. 2. Brain-derived neurotrophic factor and endocannabinoid functions in gabaergic interneuron development

   Författare :Paul Berghuis; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Formation of the cerebral cortex is controlled by tightly regulated processes: the proliferation and survival decisions of neural progenitors, radial and tangential migration of neuronal precursors, axon guidance and dendritic growth underpinning the formation of synapses. Patterning of the neocortex has been extensively studied and significant progress has been made in understanding the principles of cortical neuronal circuit formation. LÄS MER

4. 3. Role of the brain derived neurotrophic factor and inflammatory mediators in colon cancer

   Författare :Syrina Mehrabi; Malmö Cellpatologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colon Cancer; Neutrophils; Inflammation; CysLT1R; BDNF; Tumor microenvironment; Prognostic; Predictive; Diagnostic; Gene signature; Biomarkers;

   Sammanfattning : CRC is one of the most common causes of cancer death in the world. If CRC is diagnosed in the early stages, the patient's chance of survival is estimated at about 90%, with a very low probability of recurrence. The five-year DFS for CRC patients in stage III and IV drops to 63.3% and 18. LÄS MER

5. 4. Antidepressive and antipsychotic treatments : effects on nerve growth factor and brain-derived neurotrophic factor in rat brain

   Författare :Francesco Angelucci; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Recently it has been reported that depression and schizophrenia, the two major psychiatric disorders, are characterized by loss of neurons in specific brain regions. Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are proteins involved in neuronal survival and plasticity of dopaminergic, cholinergic and serotonergic neurons in the central nervous system (CNS). LÄS MER

7. 5. Post-Ischemic Housing Conditions Influence On Gene Transcription And Translation After Permanent Focal Brain Ischemia In Rats

   Författare :Li-Ru Zhao; Sektion IV; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rats; brain-derived neurotrophic factor; mRNA; nerve growth factor-induced gene A; corticosteroid receptors; in situ hybridization; Neurologi; neurophysiology; Neurology; neuropsychology; brain ischemia; enriched environment; neuropsykologi; neurofysiologi;

   Sammanfattning : Enriched environment (EE) housing significantly ameliorates neurological deficits induced by cortical brain ischemia without changing infarction size, suggesting that EE-related functional benefits are associated with neuronal plasticity events in the remaining tissue. Brain-derived neurotrophic factor (BDNF), nerve growth factor-induced gene A (NGFI-A) and corticosteroid receptors (mineralocorticoid receptor, MR; glucocorticoid receptor, GR) have been demonstrated to be involved in brain plasticity. LÄS MER