Sökning: "viral vectors"
Visar resultat 1 - 5 av 74 avhandlingar innehållade orden viral vectors.
1. Viral vectors, in innate and adaptive immunity
Sammanfattning : Recombinant viral vectors and DNA vectors induce strong immune responses in animal models. However, in clinical trials, the generation of immune responses is less robust, suggesting that further optimization and a deeper understanding of nucleic acid-based vaccines are required. LÄS MER
2. Construction of Adenovirus Vectors for Studies of Protein Function and RNA Interference
Sammanfattning : During an adenovirus infection the accumulation of alternatively spliced mRNAs is subjected to a tight temporal regulation. The IIIa protein is a structural protein expressed exclusively late after infection. LÄS MER
3. Enhancing the efficiency of viral and non-viral gene delivery vectors
Sammanfattning : Gene therapy, which involves the introduction, alteration, or deletion of genetic material within cells to treat or prevent disease, holds great promise for addressing various genetic disorders and other medical conditions. However, several challenges remain in the field, particularly concerning nucleic acid delivery into target cells. LÄS MER
4. Retargeting of adenovirus vectors. Viral ligands and cellular receptors
Sammanfattning : Gene therapy is one of the newest technologies attempted to treat human cancer. Progress in the field has however been hampered by the lack of efficient and safe vectors. Ideal vectors should specifically transduce desired cells in vivo. This thesis is devoted to the development and evaluation of retargeted adenovirus type 5 (Ad5) vectors. LÄS MER
5. Alphavirus vectors as recombinant vaccines
Sammanfattning : This thesis describes further developments of an expression system based on the alphavirus Semliki Forest virus (SFV), and its potential use as recombinant vaccine. The RNA genome of SFV contains a 3'open reading frame (ORF) encoding the structural proteins, and a 5' ORF coding for the viral replicase. LÄS MER