Sökning: "Neurotrophic factor"

Visar resultat 21 - 25 av 157 avhandlingar innehållade orden Neurotrophic factor.

  1. 21. Neurotrophic factors and their receptors structure-function relationships and signalling mechanisms

    Författare :Mikael Ryden; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :neurotrophins; nerve growth factor; brain-derived neurotrophic factor; neurotrophin-3; neurotrophin-4; p75 neurotrophin receptor; neuroblastoma; serinethreonine kinase receptors;

    Sammanfattning : Background: The development, survival and maintenance of the vertebrate nervous system requires the continuous supply of a set of polypeptides termed neurotrophic factors. Among these, the neurotrophins (NTs) and members of the transforming growth factor-B (TGF-B) superfamily have raised substantial hopes for future clinical applications. LÄS MER

  3. 22. Neuropeptides and neurotrophic factors in epilepsy: seizure suppressant actions of VEGF, NPY and galanin

    Författare :Litsa Nikitidou; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epilepsy; Gene Therapy; Neuropeptide Y; Y2 receptor; Y5 receptor; Galanin; Encapsulated cell biodelivery; Vascular endothelial growth factor; Flk-1; Hippocampus;

    Sammanfattning : Epilepsy is a severe chronic neurological disorder, affecting about 1% of the population. The disease is manifested by spontaneous recurrent seizures, caused by hypersynchronized neuronal activity due to imbalance in the brain between the inhibition and excitation. LÄS MER

  4. 23. Advancing gene therapy for epilepsy. Translational pre-clinical studies with neuropeptide Y and glial cell-line derived neurotrophic factor

    Författare :Esbjörn Melin; Epilepsicentrum; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epilepsy; Gene Therapy; neuropeptide Y NPY ; Y2 receptor; GDNF; Encapsulated cell biodelivery; seizure; In-vivo;

    Sammanfattning : Epilepsy is a neurological disorder, affecting approximately 1% of the population. The high rate of drug-resistance in epilepsy in general (30%), and temporal lobe epilepsy (TLE) in particular, pose a serious clinical problem. Thus, novel treatments for drug-resistant epilepsy is highly warranted. LÄS MER

  5. 24. On functions of neurotrophic factors in taste buds and teeth

    Författare :Irina Vukmanovic Nosrat; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Chemosensory disorders affect approximately 15% of the U.S. population and an estimated 200,000 individuals visit a doctor each year for problems with their ability to taste or smell (NIDCD). LÄS MER

  7. 25. Neurotrophic factors in peripheral nervous system development : function and specificity

    Författare :Anna Stenqvist Castelo-Branco; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neurotrophic factors control a range of activities in developing neurons, including survival, proliferation, migration and neuronal differentiation. Two classes of neurotrophic factors that are strongly linked to neuronal development of the peripheral nervous system are the neurotrophins and GDNF family ligands. LÄS MER