Sökning: "transcriptional profiling"

Visar resultat 21 - 25 av 94 avhandlingar innehållade orden transcriptional profiling.

  1. 21. Expression profiling of blood vessels in pericyte deficiency and diabetes

    Författare :Jenny Norlin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The kidney glomerulus is essential for the filtration of waste products from the blood into the urine and in controlling the volume and composition of body fluids. Injury to the glomerulus can lead to altered glomerular filtration rate, proteinuria, thickening of the glomerular basement membrane (GBM) and accumulation of mesangial cell matrix. LÄS MER

  3. 22. Profiling of microglia in inflammation, aging, and the tumor microenvironment

    Författare :Lara Friess; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In this thesis I aim to present our ongoing efforts to elucidate activation states and how these are regulated in microglia cells. An extensive body of work is dedicated to understanding how these resident immune cells can acquire certain activation states, as their roles are crucial for a great range of functions in the central nervous system – from homeostasis to pathological occurrences. LÄS MER

  4. 23. Antibody-based Profiling of Expression Patterns using Cell and Tissue Microarrays

    Författare :Sara Strömberg; Fredrik Ponten; Joakim Lundeberg; Anna Asplund; Stephen Hewitt; Uppsala universitet; []
    Nyckelord :Pathology; antibody-based proteomics; tissue microarray; cell line; immunohistochemistry; melanocytes; image analysis; biomarker; Patologi;

    Sammanfattning : In this thesis, methods to study gene and protein expression in cells and tissues were developed and utilized in combination with protein-specific antibodies, with the overall objective to attain greater understanding of protein function.To analyze protein expression in in vitro cultured cell lines, a cell microarray (CMA) was developed, facilitating antibody-based protein profiling of cell lines using immunohistochemistry (IHC). LÄS MER

  5. 24. Simultaneous profiling of cell types and lineages in neuro- and gliogenesis

    Författare :Leonie von Berlin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The mammalian brain consists of billions of highly specialized cells and trillions of connections between them. This immense complexity arises from a single layer of neuroepithelial progenitor cells. LÄS MER

  7. 25. Inferring transcriptional regulation on the promoter level and its applications to diseases

    Författare :Morana Vitezic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Gene regulation is important in maintaining cell identity and in higher organisms is a very complex process with many layers of regulation. Genome-wide transcriptional studies that define gene expression across different cells and tissues give important insights into overall gene regulation of a cell as well as the impact of dysregulation in diseases. LÄS MER