Sökning: "transcriptional profiling"
Visar resultat 11 - 15 av 94 avhandlingar innehållade orden transcriptional profiling.
11. Molecular Characterization of Genomic Amplifications in Pancreatic Cancer
Sammanfattning : Pancreatic cancer includes multiple histologic subtypes that show large differences in their clinical and biological characteristics. Despite this diversity, more than 85% of the neoplasms in the organ are malignant ductal adenocarcinomas, which are the focus of the present thesis. LÄS MER
12. Proximity Ligation and Barcoding Assays : Tools for analysis of proteins and protein complexes
Sammanfattning : Proteins are fundamental structural, enzymatic and regulatory components of cells. Analysis of proteins, such as by measuring their concentrations, characterizing their modifications, and detecting their interactions, provides insights in how biological systems work physiologically or pathologically at the molecular level. LÄS MER
13. Transcriptional profiling of human embryonic stem cells and their functional derivatives
Sammanfattning : Human embryonic stem cells (hESCs) represent populations of pluripotent, undifferentiated cells with unlimited replication capacity, and with the ability to differentiate into any functional cell type in the human body. Based on these properties, hESCs and their derivatives provide unique model systems for basic research on embryonic development. LÄS MER
14. Gene Regulatory Networks: Dynamics and Stability
Sammanfattning : Life as we know it is based on cells that use proteins and RNA to carry out metabolism, self-replication, and other essential tasks. The genes that code for these molecules are encoded in DNA, and through the processes of transcription and translation the cell expresses its genes. LÄS MER
15. Quantitative methods for profiling dynamic chromatin features
Sammanfattning : Living systems, from entire organisms down to the single cells constituting them are dynamic entities that continuously adapt and respond to their local environment. Cells achieve this through gene expression programs derived from static information encoded in the DNA made dynamic through chemical modifications at the chromatin level, collectively termed the epigenome. LÄS MER