Sökning: "time-of-flight mass spectrometry"

Visar resultat 21 - 25 av 92 avhandlingar innehållade orden time-of-flight mass spectrometry.

1. 21. New Mass Spectrometric Methods for Structure Analysis of Carboxymethyl Cellulose

   Författare :Jonas Enebro; Sigbritt Karlsson; Dane Momcilovic; Ulf Germgård; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; carboxymethyl cellulose; substituent distribution; rheology; enzyme hydrolysis; cellulase; permethylation; liquid chromatography; MALDI; ESI; mass spectrometry; Polymer chemistry; Polymerkemi;

   Sammanfattning : Carboxymethyl cellulose (CMC) is a cellulose derivative, made from cellulose by introduction of carboxymethyl groups along the molecules. The properties of CMC are affected by several parameters where the molar mass and molar mass distribution, degree of substitution (DS) and the distribution pattern along, and between, the cellulose molecules are the most prominent. LÄS MER

3. 22. Drug Metabolites Formed by Cunninghamella Fungi : Mass Spectrometric Characterization and Production for use in Doping Control

   Författare :Axel Rydevik; Mikael Hedeland; Ulf Bondesson; David Cowan; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cunninghamella blakesleeana; Cunninghamella elegans; Doping Control; Drug Metabolites; Glucuronide Production; Mass Spectrometry; Reactive Metabolites; Reference Material; Structural Characterization; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

   Sammanfattning : This thesis describes the in vitro production of drug metabolites using fungi of the Cunninghamella species. The metabolites were characterized with mainly liquid chromatography-mass spectrometry using ion-trap and quadrupole-time-of-flight instruments. A fungal in vitro model has several advantages e.g. LÄS MER

4. 23. Imaging mass spectrometry for in situ lipidomics: from cell structures to cardiac tissue

   Författare :Sanna Sämfors; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Myocardial infarction; PC12 cells; Cell membrane; Mass spectrometry imaging; Sample preparation; Lipidomics; ToF-SIMS; Gas cluster ion beam;

   Sammanfattning : Imaging of cells and tissues is important for studying different processes within biological systems due to the spatial information provided for different molecular species during imaging. One powerful imaging technique is mass spectrometry imaging (MSI). LÄS MER

5. 24. Reactivity of Metal Clusters with Diatomic Molecules

   Författare :Lotta Holmgren; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nbn; cluster; reactivity; Rhn; NO; D2; CO; N2; laser vaporization; Wn; Nin; photoionization; time-of-flight mass spectrometer; ionization potential; Cun; O2; Vn;

   Sammanfattning : The reactivity of transition-metal clusters, in the approximate size range 10-60 atoms, with diatomic molecules has been investigated. A pulsed beam of neutral clusters is produced by a laser-vaporization source and passed through a low-pressure reaction cell containing the reactive gas. LÄS MER

7. 25. Protein mass spectrometry in the drug discovery process

   Författare :Agneta Tjernberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Mass spectrometry; ESI-MS; MALDI-TOF MS; drug discovery; protein characterization; dissociation constants;

   Sammanfattning : Most targets for drug discovery are proteins. Drug discovery includes target identification and validation, structural biology, lead generation, lead optimisation, pre-clinical development and clinical trials. The overall aim of this thesis is to apply protein mass spectrometry (MS) in the early drug discovery process. LÄS MER