Sökning: "threonine synthase"

Visar resultat 6 - 8 av 8 avhandlingar innehållade orden threonine synthase.

  1. 6. On certain genetic and metabolic risk factors for carotid stenosis and stroke

    Författare :Pär Wanby; Lars Brudin; Martin Carlsson; Milita Crisby; Linköpings universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Carotid artery diseases; Carrier proteins; genetics; Cerebrovascular accident; Cerebrovascular disorders; Genetic predisposition to disease; Polymorphism; genetic; Medicine; Medicin; Medicin;

    Sammanfattning : The present study evaluated genetic and metabolic factors influencing the risk of acute cerebrovascular disease (CVD) and internal carotid artery stenosis (ICA stenosis) in a Swedish community. The threonine (T) containing protein of the FABP2 A54T gene polymorphism has a greater affinity for long chain fatty acids (FFAs) than the alanine (A) containing protein. LÄS MER

  3. 7. The role of mTor in the pathogenesis of tau-related pathologies in Alzheimer disease

    Författare :Zhi Tang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : An important neurophathological hallmark of Alzheimer disease (AD) is the progressive formation of neurofibrillary tangles composed of aberrant hyperphosphorylated tau aggregates. Evidence from human postmortem AD brains and in vitro and in vivo rapamycin-treated drug models implicated an abnormal accumulation of the mammalian target of rapamycin (mTor) in AD brains. LÄS MER

  4. 8. Role of p70 S6 kinase in the formation of tau pathologies in Alzheimer’s disease

    Författare :Wen-Lin An; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Alzheimer s disease; p70 S6 kinase; tau; protein translation; accumulation; phosphorylation;

    Sammanfattning : One of the important neuropathological features of Alzheimer's disease (AD) is the tau pathology seen as accumulation and hyperphosphorylation of this protein. Evidences showed that tau could be phosphorylated mostly at serine/threonine (S/T) residues by many kinases, including protein kinase B, glycogen synthase kinase (GSK)-3beta, extracellular signal-regulated kinase (ERK1/2), ERK1/2 kinase (MEK1/2), c-Jun Nterminal kinase (JNK), and p38. LÄS MER