Sökning: "soft drug"

Visar resultat 6 - 10 av 44 avhandlingar innehållade orden soft drug.

  1. 6. Experimental and computational investigation of affinity and selectivity factors in CYP2D6 and CYP3A4 mediated metabolism

    Författare :Britta Bonn; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cytochrome P450; in vitro metabolism; biotransformation; computational modeling; drug design;

    Sammanfattning : The assessment of ADME properties and metabolic behavior of a drug is central in drug discovery and drug design. The main target for studies of metabolic properties is the Cytochrome P450 (CYP), which is responsible for the metabolism of a majority of drugs on the market and consequently also involved in many drug-drug interactions. LÄS MER

  3. 7. Intraocular Microdialysis

    Författare :Janina Waga; Lund Oftalmologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ophtalmology; pharmacokinetics; drug adminstration; vitreous body; Microdialysis; eye; Oftalmologi;

    Sammanfattning : The method of microdialysis has been adapted for ocular use. It is a technique for monitoring concentrations of different molecules in a tissue in vivo. It is based on the principle of diffusion through a semipermeable membrane. The membrane is mounted on a soft plastic shaft, connected to an inlet and an outlet tube. LÄS MER

  4. 8. Markers for clinical outcome and therapy response in soft tissue sarcomas

    Författare :Jan Åhlen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Soft-tissue sarcomas (STSs) constitute a heterogeneous group of rare but aggressive tumors that originate from mesenchymal cells in almost any part of the body. Gastrointestinal stromal tumor (GIST), located in the gastrointestinal tract, is the most common type of STS. LÄS MER

  5. 9. 3D Reconstruction of Porous and Poorly Conductive Soft Materials using FIB-SEM Tomography

    Författare :Cecilia Fager; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; insulating material; 3D; interconnectivity; focused ion beam; tomography; polymer film; scanning electron microscopy;

    Sammanfattning : Focused ion beam combined with scanning electron microscope (FIB-SEM) is a powerful tool that can be utilised to reveal the internal microstructure of materials. It basically uses ions to make cross-sections with high precision and electrons to image the cross-section surface with high spatial resolution. LÄS MER

  7. 10. Molecular cytogenetic studies of soft tissue sarcoma : with focus on prognosis and acquired events

    Författare :Wen-Hui Weng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Soft tissue sarcomas (STSs) constitute a heterogenous group of highly aggressive tumors of mesenchymal origin that account for approximately 1% of all human malignancies. With the aim of eventually improving the diagnostics and clinical handling of these patients, considerable research efforts have been invested to understand the natural history of these tumors. LÄS MER