Sökning: "in vitro metabolism"

Visar resultat 1 - 5 av 368 avhandlingar innehållade orden in vitro metabolism.

  1. 1. Stimulus-Section Coupling in Endocrine Cell Models

    Detta är en avhandling från Department of Clinical Sciences, Lund University

    Författare :Lotta Andersson; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2015]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Detailed understanding of biological systems governing specific mechanisms and pathways is essential in the development of novel disease therapies. Stimulus-secretion coupling in hormone secreting cells is a complex system of pathways that link activation of cellular processes by i.e. nutrients to the release of hormone. LÄS MER

  2. 2. Control of metabolism and hormone secretion from pancreatic alpha and beta cells

    Detta är en avhandling från Molecular Metabolism

    Författare :Jelena Stamenkovic; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CLOCK genes; insulin; glucagon; metabolites; mitochondria; knock out;

    Sammanfattning : Type 2 Diabetes (T2D) is a multifactorial disease, which has made it difficult to resolve its pathophysiology. We investigated processes that could contribute to the development of T2D. LÄS MER

  3. 3. First-pass Intestinal Metabolism of Drugs Experiences from in vitro, in vivo and simulation studies

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Helena Anna Thörn; Uppsala universitet.; [2012]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; metabolism; CYP3A4; CYP2C9; CYP2D6; UGT; glucuronidation; physiologically based pharmacokinetic model; modelling; Biopharmaceutics; Biofarmaci;

    Sammanfattning : The bioavailability of a drug can be described as the fraction of an orally administered dose that reaches the systemic circulation and is often limited by first-pass metabolism in the gut and the liver. It is important to have knowledge about these processes since the systemic blood drug concentration is tightly connected to the effect of the drug. LÄS MER

  4. 4. Metabolism of felodipine : mechanistic and kinetic studies in vitro - in vivo correlations

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Catharina Bäärnhielm; Uppsala universitet.; [1986]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Sammanfattning : .... LÄS MER

  5. 5. Metabolism of two beta-adrenoceptor antagonists, alprenolol and metoprolol, in different species : in-vitro and in-vivo correlations

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Inger Skånberg; Uppsala universitet.; [1980]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Sammanfattning : .... LÄS MER