Sökning: "drug solubility"

Visar resultat 1 - 5 av 58 avhandlingar innehållade orden drug solubility.

1. 1. Computational Analysis of Aqueous Drug Solubility – Influence of the Solid State

   Författare :Carola Wassvik; Per Artursson; Anders G Holmén; Valentino J. Stella; Uppsala universitet; []
   Nyckelord :Pharmaceutics; intrinsic solubility; solubility prediction; drug solubility; solid state; melting point; enthalpy of melting; entropy of melting; solvation; free energy of hydration; QSPR; multivariate analysis; PCA; PLS; Galenisk farmaci;

   Sammanfattning : Aqueous solubility is a key parameter influencing the bioavailability of drugs and drug candidates. In this thesis computational models for the prediction of aqueous drug solubility were explored. LÄS MER

3. 2. Computational and Experimental Models for the Prediction of Intestinal Drug Solubility and Absorption

   Författare :Christel A. S. Bergström; Per Artursson; Han van de Waterbeemd; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; aqueous drug solubility; melting point; intestinal drug permeability; pH-dependent solubility; multivariate data analysis; molecular descriptors; molecular surface area; in silico modeling; drug absorption; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

   Sammanfattning : New effective experimental techniques in medicinal chemistry and pharmacology have resulted in a vast increase in the number of pharmacologically interesting compounds. However, the number of new drugs undergoing clinical trial has not augmented at the same pace, which in part has been attributed to poor absorption of the compounds. LÄS MER

4. 3. Drug Dissolution under Physiologically Relevant Conditions In Vitro and In Vivo

   Författare :Eva Persson; Hans Lennernäs; Bertil Abrahamsson; Peter Langguth; Uppsala universitet; []
   Nyckelord :Biopharmacy; solubility; drug dissolution; food effects; poorly soluble drugs; P-gp inhibition; drug absorption; pemeability; bile acids; phospholipids; human intestinal fluid; simulated intestinal fluid; neutral lipids; solid phase extraction; HPLC; Efflux; Biofarmaci;

   Sammanfattning : The general aim of the present project was to increase the understanding of the in vivo dissolution of poorly soluble drugs and thereby improve possibility to predict in vivo solubility from substance properties. Increased understanding of the in vivo limitations of drug solubility could potentially also generate ideas for improved formulation principles for poorly soluble compounds and more relevant in vitro dissolution test methods used in formulation development. LÄS MER

5. 4. Microscopic views of drug solubility

   Författare :Laban Bondesson; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Bioengineering; Bioteknik;

   Sammanfattning : The development of computational models for predicting drug solubility has increased drastically during the last decades. Nevertheless these models still have diffculties to estimate the aqueous solubility as accurate as desired. LÄS MER

7. 5. Microscopic Interpretations of Drug Solubility

   Författare :Laban Bondesson; Hans Ågren; Toomas Tamm; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; pharmaceutical chemistry; physical chemistry; molecular physics; computer science; Chemical engineering; Kemiteknik;

   Sammanfattning : .... LÄS MER