Sökning: "receptor dimerization"

Visar resultat 16 - 20 av 26 avhandlingar innehållade orden receptor dimerization.

  1. 16. Keratinocyte differentiation. Involvement of the growth hormon (GH)/insulinlike growth factor1 (IGFI) axis and IGF1 post receptor signaling

    Författare :Elisabeth Björntorp Mark; Göteborgs universitet; []
    Nyckelord :IGF1R; GH; Id1; keratinocytes; psoriasis;

    Sammanfattning : At cellular level, little is known about the genes that regulate keratinocyte differentiation andproliferation. Psoriasis is regarded as a T-cell mediated inflammatory disease with hyperproliferativekeratinocytes. LÄS MER

  3. 17. Growth hormone, JAKs and STATs : a model cytokine signal transduction system

    Författare :Tim Wood; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The haematopoietic cytokine family of signalling molecules comprises a variety of polypeptides which have pleiotropic effects on cell differentiation, tissue development and homeostasis. The family includes several interleukins, a variety of growth and colony stimulating factors, erythropoietin, leukaemia inhibitory factor, ciliary neurotrophic factor, the interferons, as well as leptin, prolactin and growth hormone. LÄS MER

  4. 18. Exploring the role of PDGF-D in health and disease

    Författare :Hanna Gladh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The platelet-derived growth factors (PDGF) and their receptors (PDGFRs) regulate growth and migration in cell populations of mesenchymal origin. The PDGF signaling system is vital for development, in neural crest formation, in organogenesis, and in maturation of the microvasculature. In the adult, PDGFs are needed to maintain homeostasis. LÄS MER

  5. 19. GH Secretion in children. Methodological aspects of determining immunoreactive and bioactive isoforms

    Författare :Chatarina Löfqvist; Göteborgs universitet; []
    Nyckelord :Growth hormone; immunoassay; cross-reactivity; standard; antibody; insulin-like growth factor 1; reference values;

    Sammanfattning : A child's hormone-dependent growth is dependent on multiple factors, although linear growth is closely associated with levels of growth hormone (GH) secretion. As GH in serum exists in several isoforms, some of which may not be identified by immunoassay, possible alterations in the secretion of these different isoforms in childhood may influence growth and/or metabolism. LÄS MER

  7. 20. Stem Cell Factor Induced Signal Transduction

    Författare :Johan Lennartsson; Christer Larsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Onkologi; Oncology; Onkologi; molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : Stem Cell Factor (SCF) can function as a survival factor, a mitogen or a chemoattractant depending on cell type. Binding of SCF to c-Kit induces dimerization and subsequent autophosphorylation of the receptor. This thesis describes the intracellular signal transduction elicited by c-Kit. LÄS MER