Sökning: "receptor dimerization"

Visar resultat 21 - 25 av 26 avhandlingar innehållade orden receptor dimerization.

  1. 21. Affibody Molecules Targeting VEGFR2 - Two Turns Off and Four Turns On

    Författare :Rezan Güler; John Löfblom; Stefan Ståhl; Dario Neri; KTH; []
    Nyckelord :Protein engineering; affibody molecules; VEGFR2; angiogenesis; Bioteknologi; Biotechnology;

    Sammanfattning : The notion of employing proteins as drugs traces back several decades. As recombinant DNA technology emerged, it became a powerful tool for the tailoring of protein traits via genetic approaches - so-called protein engineering. LÄS MER

  3. 22. Polypeptide functionalized gold nanoparticles for bioanalytical applications

    Författare :Robert Selegård; Bo Liedberg; Karin Enander; Daniel Aili; Wilhelm Robert Glomm; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Detection strategies that allow for simple, rapid, cost efficient and sensitive monitoring of proteins and their interactions with biomolecules are of great importance in drug development and diagnostics. This thesis describes the development of bioanalytical applications based on the tunable self-assembly of gold nanoparticles functionalized with a de novo designed polypeptide. LÄS MER

  4. 23. Identification of novel pathways of regulation of AHR and HIF-­1 function

    Författare :Michael Gralla; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mammalian bHLH-Pas (basic HLH (helix-loop-helix)-PER-ARNT-SIM) proteins belong to the bHLH superfamily of transcription factors. Members of the family have a broad spectrum of functions that among others sense and regulate the cellular response to physiological signals such as low oxygen levels (hypoxia), or environmental signals such as toxins. LÄS MER

  5. 24. Activation of the novel PDGFS by plasminogen activators in tumorigenesis

    Författare :Monika Ehnman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Members of the platelet-derived growth factor (PDGF) family are mitogens for cells of a mesenchymal origin and have important functions both during development and in the adult. Their role in developmental processes has been extensively investigated by methodical targeted gene inactivations, revealing critical involvement in microvascular pericyte recruitment, neural crest development and alveogenesis. LÄS MER

  7. 25. Regulation of transcription factors by XAP-2 : a member of the Hsp90 chaperone complex

    Författare :Petra Berg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The AhR belongs to the bHLH/PAS family of transcription factors, which mediates biological effects of environmental pollutants such as 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD). In the absence of ligand the AhR is located in the cytoplasmatic compartment of the cell associated with the molecular chaperone Hsp90, p23 and a member of the immunophilin family of proteins, XAP-2. LÄS MER