Sökning: "rat primary cortical neurons"

Visar resultat 6 - 8 av 8 avhandlingar innehållade orden rat primary cortical neurons.

1. 6. A study of b-secretase cleaved Alzheimer amyloid precursor protein

   Författare :Kristina Sennvik; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Alzheimer's disease (AD) is characterized by the degeneration and loss of neurons, intracellular neurofibrillary tangles and the accumulation of extracellular senile plaques consisting mainly of beta-amyloid (A-beta). A-beta is generated from the amyloid precursor protein (APP) through sequential cleavage by proteases P- and gamma-secretase. LÄS MER

3. 7. Apoptotic cell death in neural stem cells exposed to toxic stimuli

   Författare :Christoffer Tamm; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Neural stem cells (NSCs) play an important role in the developing nervous system and adulthood, where mitotic regions of the brain such as the subventricular zone (SVZ) remain active. In spite of the immense interest in NSC research, little is known about the biochemical regulation by which NSCs undergo cell death in the course of normal physiology or in response to neurotoxic insults. LÄS MER

4. 8. Spinal cord injury : mechanical and molecular aspects

   Författare :Anna Josephson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Spinal cord; syringomyelia; MRI; fMRI; neurotrophin; Nogo; Nogo receptor; regulation;

   Sammanfattning : Traumatic spinal cord injury leads to full or partial paralysis and loss of sensation below the level of injury. The annual incidence of spinal cord injury in the United States is 3-5 per 100,000 and in Sweden is 1.5-2 per 100,000. This translates to 11,000 new cases of traumatic spinal cord injury in the US and 150 in Sweden each year. LÄS MER