Avancerad sökning
Hittade 3 avhandlingar som matchar ovanstående sökkriterier.
1. Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors : Targeting Different Genotypes and Drug-Resistant Variants
Sammanfattning : Since the first approved hepatitis C virus (HCV) NS3 protease inhibitors in 2011, numerous direct acting antivirals (DAAs) have reached late stages of clinical trials. Today, several combination therapies, based on different DAAs, with or without the need of pegylated interferon-α injection, are available for chronic HCV infections. LÄS MER
2. Design & Synthesis of Protein Interacting Affinity Ligands and Protease Inhibitors
Sammanfattning : There is a growing need of both protein drugs and synthetic drugs in the fight against many life-threatening diseases. The first part of this thesis deals with the design and synthesis of high affinity binding ligands for the purification of protein drugs. LÄS MER
3. Synthetic studies of heterocyclic natural products
Sammanfattning : The methods that were developed for the synthesis of the heterocyclic natural products luotonin A, ophiuroidine, cephalandole B, and the indol-3-yl-benzoxazinones of cephalandole A are described in this thesis. The reoccurrence of the 4(3H)-quinazolinone structure is a common theme throughout these studies, and an overview of some quinazoline chemistry is introduced in the first chapter. LÄS MER