Sökning: "demethylation"

Visar resultat 1 - 5 av 46 avhandlingar innehållade ordet demethylation.

  1. 1. Mercury species transformations in marine and biological systems studied by isotope dilution mass spectrometry and stable isotope tracers

    Författare :Lars Lambertsson; Wolfgang Frech; John Munthe; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; Mercury; methylmercury; ethylmercury; Thimerosal; speciation; methylation; demethylation; brackish water sediment; natural waters; GC-ICP-MS; species-specific isotope dilution; isotope enriched tracers; Analytisk kemi; Analytical chemistry; Analytisk kemi; analytisk kemi; Analytical Chemistry;

    Sammanfattning : This thesis focuses on the implementation of species-specific isotope dilution (SSID) methodology and stable isotope tracers to determine mercury species occurrence and transformation processes in-situ and during sample treatment. Isotope enriched tracers of methyl-, ethyl- and inorganic mercury were synthesised and applied in different combinations to marine and biological samples. LÄS MER

  2. 2. Unraveling the importance of solid and adsorbed phase mercury speciation for methylmercury formation, evasion and bioaccumulation

    Författare :Sofi Jonsson; Erik Björn; Ulf Skyllberg; Erik Lundberg; Per Persson; Robert Mason; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mercury; methylmercury; aquatic systems; estuary; Hg; MeHg; bioaccumulation; methylation; demethylation; evasion; sediment; water; terrestrial sources; atmospheric sources; climate change; eutrophication;

    Sammanfattning : Monomethylmercury, MeHg, is formed under anoxic conditions in waters, sediments and soils and then bioaccumulated and biomagnified in aquatic food webs, negatively effecting both human and wildlife health. It is generally accepted that precipitation of mercury, Hg, and adsorption of Hg to e.g. LÄS MER

  3. 3. Formation, uptake and bioaccumulation of methylmercury in coastal seas : a baltic sea case study

    Författare :Aleksandra Skrobonja; Erik Björn; Agneta Andersson; Anne L. Soerensen; Marc Amyot; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mercury; methylmercury; bioaccumulation; mesososm; isotope tracers; methylation; demethylation; stability constant; kinetic model; coastal sea; ICPMS; LC-MS MS;

    Sammanfattning : Methylmercury (MeHg) is a potent neurotoxin which can bioaccumulate to harmful levels in aquatic food webs. Methylmercury formation is a predominantly biotic process which involves phylogenically diverse microorganisms (e.g. iron- or sulfate-reducing bacteria). LÄS MER

  4. 4. Studies of Budding Yeast Transcription Factors Acting Downstream of Nutrient Signaling Pathways

    Författare :Niklas Nordberg; Hans Ronne; Anders Blomberg; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Budding yeast; nutrient signaling; glucose repression; aging; caloric restriction; JmjC; histone demethylation; Mig1; Mig2; Mig3; Gis1; Rph1; Molekylär genetik; Molecular Genetics;

    Sammanfattning : Being able to respond to extracellular cues such as nutrients and growth factors is of vital importance to all living cells. Pathways have therefore evolved which can sense the extracellular status, transmit a signal through the cell and affect gene expression, which ultimately enables adaptation. LÄS MER

  5. 5. Formation of active metabolites by demethylation and hydroxylation of tricyclic antidepressants in man

    Författare :Britt Mellström; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Sammanfattning : .... LÄS MER