Sökning: "primary cutaneous melanoma"

Visar resultat 1 - 5 av 28 avhandlingar innehållade orden primary cutaneous melanoma.

  1. 1. Genomic analysis of primary and metastatic malignant melanoma

    Författare :Katja Harbst; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; next-generation sequencing; microarray; progression; molecular grade; subtype; melanoma;

    Sammanfattning : “Cutaneous melanoma is a most unpredictable lesion” wrote Alexander Breslow in 1970. He was one of the first to predict outcome in melanoma patients, based on the thickness of the primary tumor, and today this parameter bears his name and remains the main prognostic factor in melanoma. LÄS MER

  3. 2. Cutaneous melanoma in children and adolescents and aspects of naevus phenotype in melanoma risk assessment

    Författare :Pia Karlsson; Inger Rosdahl; Johan Hansson; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; melanoma; naevus; childhood; adolescence; prevention; epidemiology; Dermatology and venerology; Dermatologi och venerologi;

    Sammanfattning : Cutaneous malignant melanoma (CMM) is one of the most rapidly increasing cancers in the Swedish population. The aetiology of melanoma is a complex interplay between genetics, host characteristics and environmental factors. LÄS MER

  4. 3. Studies of molecular features and novel prognostic biomarkers of cutaneous melanoma

    Författare :Iva Johansson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; primary cutaneous melanoma; chronic sun-damage; chronic sun-damage skin; gene expression profiling; immunohistochemistry; tertiary lymphoid structures;

    Sammanfattning : Cutaneous malignant melanoma is a highly heterogeneous disease. Immunotherapy has revolutionized the treatment of stage IV disease and is now successfully administered as adjuvant treatment in stage III and soon in stage II. Correct identification of the patients at high risk for progressive disease who will benefit from the treatment is crucial. LÄS MER

  5. 4. Cutaneous malignant melanoma : body site, sun exposure, genetic factors and prognosis

    Författare :Daniela Gordon; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Melanoma;

    Sammanfattning : Background: The interplay between tumor site, ultraviolet radiation (UVR) exposure, genetic factors and various epidemiological parameters of cutaneous melanoma is complex. In this thesis, we aimed to investigate the impact of detailed body site of the primary tumor beyond the conventional and strictly anatomic division of the head-neck, trunk, upper- and lower extremities, focusing on body site division according to UVR exposure patterns in relation to risk, outcome and other factors. LÄS MER

  7. 5. Molecular genetics of cutaneous malignant melanoma

    Författare :Malihe Eskandarpour; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cutaneous malignant melanoma is an aggressive tumor of melanocytes in the skin with rapidly increasing incidence. Patients with advanced disease have a poor prognosis since the tumor is usually resistant to current therapies. Therefore, the development of novel strategies for preventing and treating melanoma is important. LÄS MER