Sökning: "polyclonal activation"

Visar resultat 6 - 10 av 41 avhandlingar innehållade orden polyclonal activation.

  1. 6. Recognition requirements and regulatory events directing T cell responses

    Författare :Martin Gullberg; Eva-Lotta Larsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; T cell growth factor production; Lyt-2-positive T suppressor cell; Lyt-2-positive cytotoxic T lymphocytes; activation requirements of T lymphocytes; blocking of T cell functions;

    Sammanfattning : The present study has considered cellular and molecular requirements in T cell responses. The central role of T cell growth factors (TCGF) in T cell responses prompted us to study the regulatory events directing TCGF production in lectin stimulated cultures. LÄS MER

  3. 7. Malaria, B lymphocytes and Epstein-Barr virus : emerging concepts on Burkitt's lymphoma pathogenesis

    Författare :Daria Donati; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Malaria; Plasmodium falciparum; B lymphocytes; polyclonal activation; hypergammaglobulenemia; EpsteinBarr virus; endemic Burkitt s lymphoma.;

    Sammanfattning : Plasmodium falciparum and Epstein-Barr virus (EBV) infections are recognized co-factors in the genesis of endemic Burkitt's Lymphoma (eBL), the most common paediatric cancer in equatorial Africa. This thesis work examines and discusses interactions between Pfalciparum and EBV that could promote the emergence of eBL. LÄS MER

  4. 8. Regulation of the pro-apoptotic protein Bim by T cell receptor triggering in human T cells

    Författare :Elena Sandalova; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Bim; Apoptosis; Mitochondria; CTLs; AICD; TCR activation;

    Sammanfattning : Bim is a significant pro-apoptotic member of Bcl-2 family of proteins; it is proved to be an important regulator of apoptosis: over the years it has been shown to play a pivotal role for the development and maintenance of homeostasis in many cellular systems and tissues. The Bcl-2 family of proteins is a group of key regulators of the mitochondrial, or intrinsic, pathway of apoptosis. LÄS MER

  5. 9. Mechanisms underlying impaired humoral immunity in primary and chronic HIV-1 infection

    Författare :Kehmia Titanji; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1 infection; HIV-2 infection; B cells; primary HIV-1 infection; immune activation; hypergammaglobulinemia; long-term humoral immunity; antiretroviral therapy;

    Sammanfattning : B cells of HIV-1-infected patients have both phenotypic and functional dysfunctions which may be important in HIV-1 pathogenesis. Immune activation during HIV infection is an essential part of the body s defense against the virus, but may be the root cause of B cell dysfunctions. LÄS MER

  7. 10. Impact of malaria on B-cell homeostasis and Epstein-Barr virus reactivation : endemic Burkitt's lymphoma pathogenesis

    Författare :Arnaud Chêne; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Over recent years, the concept that many diseases can be aetiologically linked to infection by more than one pathogen has gained increased attention and awareness. Plasmodium falciparum (P. LÄS MER