Sökning: "long-term humoral immunity"
Visar resultat 1 - 5 av 12 avhandlingar innehållade orden long-term humoral immunity.
1. Varicella immunity and vaccination
Sammanfattning : Varicella-zoster virus (VZV) is an air-borne, extremely contagious herpesvirus. It causes chickenpox, which usually is a benign illness in childhood. Adults, pregnant women and immunocompromised patients often get a severe disease with complications. After infection the virus stays latent in sensory ganglia. LÄS MER
2. Herpesvirus Infection and Immunity in Neurocognitive Disorders
Sammanfattning : Herpesviruses have co-speciated with several vertebrate and invertebrate animals throughout the history of evolution. In the immunocompetent human host, primary infection is usually benign, whereafter the virus is brought into life-long latency. LÄS MER
3. Mechanisms underlying impaired humoral immunity in primary and chronic HIV-1 infection
Sammanfattning : B cells of HIV-1-infected patients have both phenotypic and functional dysfunctions which may be important in HIV-1 pathogenesis. Immune activation during HIV infection is an essential part of the body s defense against the virus, but may be the root cause of B cell dysfunctions. LÄS MER
4. Humoral immunity during primate lentivirus infection : evaluation of B cell apoptosis and engineering of virus specific antibodies
Sammanfattning : The focus of this project was to evaluate the contribution of the humoral immunity in controlling infection with primate lentiviruses - an area which has implications both for vaccine design as well as for understanding of the pathogenesis of the disease. The first goal was to generate efficient neutralizing reagents which could be used for passive immunotherapy trials, preferably in the macaque system, and to investigate if peptide immunogens could elicit such antibodies. LÄS MER
5. Studies on Potency and breadth of HIV-1, HIV-2 and SIV neutralizing antibody responses
Sammanfattning : Even though the relative contribution of neutralizing antibodies (Nab) to prevent progression to AIDS during HIV-1 infection is still unclear, the induction of broadly NAb directed against HIV-1 through vaccination is considered to represent an important goal for the development of HIV-1 vaccines. Factors contributing to the induction of NAb may include the strength and duration of antigenic stimulation, the preservation of CD4+ T and B cells, the conformation of the HIV-1 envelope glycoprotein complex (Env), and the evolution of Env during infection. LÄS MER