Sökning: "primary HIV-1 infection"

Visar resultat 1 - 5 av 57 avhandlingar innehållade orden primary HIV-1 infection.

1. 1. HIV-1 infection of the central nervous system. Markers of pathogenesis and antiretroviral treatment effects

   Författare :Sahra Abdulle; Göteborgs universitet; []
   Nyckelord :HIV-1; cerebrospinal fluid; antiretroviral therapy; neopterin; beta2-microglobulin; CSF HIV-1 RNA; blood-brain barrier; IgG index; HIV-related neurological diseases; AIDS Dementia Complex; neurofilament protein; HIV-1 genetic subtypes;

   Sammanfattning : Human immunodeficiency virus type 1 (HIV-1) invades the central nervous system (CNS) early in the course of infection and either directly or through opportunistic infections causes a spectrum of neurological complications. The most severe manifestation of HIV-1 CNS infection is AIDS Dementia Complex (ADC), which occurs in approximately 20% of untreated patients with AIDS. LÄS MER

3. 2. Development of novel molecular and microfluidics tools for identification and characterization of latent HIV-1 reservoir

   Författare :Wang Zhang; Aman Russom; Ujjwal Neogi; Afshin Ahmadian; Utkan Demirci; KTH; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV-1; Latent HIV-1 reservoir; HIV-1 characterization; Microfludics; Molecular detection; Medical Technology; Medicinsk teknologi;

   Sammanfattning : The existence of latent HIV-1 reservoir (LR) in all HIV-1 infected patients serves as a major obstacle to completely cure HIV-1 infection. However, up to now there is still no available assay that provides an accurate measurement of the reservoir size. LÄS MER

4. 3. Primary HIV-1 infection : diagnostic, prognostic, and therapeutic aspects

   Författare :Stefan Lindbäck; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :primary HIV- I infection; diagnosis; prognosis; HIV-RNA; antiretroviral treatment; primary HIV-1 infection; diagnosis; prognosis; HIV-RNA; antiretroviral treatment;

   Sammanfattning : Primary HIV-1 infection (PHI) is usually defined as a mononucleosis-like illness associated with seroconversion to HIV. In earlier studies using 1st generation antibody tests, the duration of the 'window period' from infection to detection of specific HIV-antibodies, could be 2 to 3 months, or longer. LÄS MER

5. 4. HIV-1 envelope protein gp120. Glycovirology of the V3 loop

   Författare :Britt Losman; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AIDS; HIV-1; Carbohydrates; V3-region; V1-region; Coreceptors;

   Sammanfattning : The human immunodeficiency virus type 1 (HIV-1) infection usually is lethal as a consequence of the acquired immunodeficiency syndrome (AIDS). HIV-1 is an enveloped virus and the trimeric envelope glycoprotein complex, gp120/gp41, is responsible for binding of the virus both to the primary cellular receptor CD4 and the coreceptors, CXCR4 and CCR5. LÄS MER

7. 5. Aspects of immune activation in HIV-1 infection

   Författare :Piotr Nowak; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :immune activation; HMGB1; PHI; HIV-1 LTR-transcription; cytokines; chemokines;

   Sammanfattning : Abnormal immune system activation is central in HIV-1 pathogenesis leading to CD4+ T-cell depletion and inappropriate immune responses. Disease stage and HIV load strongly correlate with the immune activation level which decreases under antiretroviral therapy (ART). LÄS MER