Sökning: "polyclonal activation"
Visar resultat 1 - 5 av 41 avhandlingar innehållade orden polyclonal activation.
1. Heavy Metal Superantigen : Genetic Regulation of Lymphocyte Activation by HgC12
Sammanfattning : Injections of subtoxic doses of HgCl2 (mercuric chloride) cause a systemic autoimmune disease in genetically predisposed rats and mice. My work was designed to elucidate how HgCl2 induces lymphocyte activation and how the response to HgCl2 is regulated in susceptible and resistant strains. LÄS MER
2. Perspectives on the Biological Role of Human Prostasomes
Sammanfattning : Prostasomes are extracellularly occurring organelles which are secreted in human semen by the prostate gland. Prostasomes have several known biological activities, but their physiological function is still unclear. In this thesis some new aspects were studied on the biological role of the prostasomes. LÄS MER
3. Heavy metal-induced activation of the murine immune system and autoimmunity : a comparative study of mercury and silver
Sammanfattning : The activation and proliferation ofT- and B-cells induced by treatment with mercuric chloride (HgC12) or silver·nitrate (AgN03) was studied in mouse strains genetically susceptible (SJL, A. SW, A.TH, BALE/C) or resistant (A.TL, BALB. LÄS MER
4. Immune activation during HIV-1 infection : implication for B cell dysfunctions and therapy monitoring
Sammanfattning : Aberrant activation of cells of the immune system plays a major role in the pathogenesis of HIV infection. The major aims of the thesis were: (a) to measure the effects of current antiretroviral therapy on immune activation through the analysis of soluble activation markers; (b) to evaluate the extent of T and B cell immune activation in relation to immunological and virological parameters; (c) to analyse the T-B cell molecular pathway leading to hyperactivation of B cells and loss of B cell function. LÄS MER
5. Mechanisms influencing activation and survival of normal and malignant lymphoid cells in the testis
Sammanfattning : Acute lymphoblastic leukaemia (ALL) is the most common childhood malignancy and the testis is the third most common site of relapse after treatment. Testicular function is regulated by pituitary hormones, but the testicular microenvironment is also locally regulated through cell-cell interactions and by paracrine factors. LÄS MER