Sökning: "polyclonal activation"

Visar resultat 21 - 25 av 41 avhandlingar innehållade orden polyclonal activation.

  1. 21. Mechanisms of pain in autoimmunity : the role of antibodies

    Författare :Gustaf Wigerblad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic pain in autoimmune diseases, like rheumatoid arthritis (RA), is a common and life- changing problem for many patients. Treatment is usually aimed at reducing inflammation and preserving the function of affected tissues. Chronic pain, however, often persists despite optimal disease control. LÄS MER

  3. 22. Cellular and molecular mechanisms in immune mediated hepatic fibrosis. A study of the inflammatory syndrome and fibrosis development of the NIF mouse liver

    Författare :Julia Nilsson; Autoimmunitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fibrosis; liver; mouse model; NKT cells; type 2 inflammation; inflammasome;

    Sammanfattning : Fibrosis is the result of dysregulated inflammation and tissue repair, and is characterized by the excessive accumulation of extra cellular matrix (ECM) proteins. It causes detrimental effects to the afflicted tissue and can subsequently lead to organ failure. LÄS MER

  4. 23. Molecular evolution of a C5aR antagonist against inflammatory disease

    Författare :Erika Gustafsson; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : New anti-inflammatory drugs with fewer adverse effects than existing drugs may prove to be useful in the treatment of several inflammatory disorders. A critical step in acute inflammation is the infiltration of neutrophils into tissues. LÄS MER

  5. 24. HIV-1 infection and loss of serological memory : the role of altered expression of B-cell chemokine receptors, timing of HAART and impaired antibody affinity maturation

    Författare :Alberto Cagigi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Currently, big efforts in HIV-1 research are devoted to the design of a HIV-1 vaccine. However, no successful vaccine is yet available, also due to the lack of basic knowledge in HIV-1 pathogenesis which is still profound. LÄS MER

  7. 25. Expansion and genetic modification of human natural killer cells for adoptive immunotherapy of cancer

    Författare :Tolga Sutlu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A century after the initial proposition that the immune system has the capacity to fight against tumors, evading destruction by immune cells is now well recognized as a hallmark of cancer. Recent decades have witnessed extraordinary improvements in the use of immunotherapy against malignancies and adoptive transfer of Natural Killer (NK) cells stands among promising tools in the fight against cancer. LÄS MER