Sökning: "HIV-1 infection"
Visar resultat 1 - 5 av 199 avhandlingar innehållade orden HIV-1 infection.
1. On cerebrospinal fluid markers of HIV-1 infection
Sammanfattning : HIV-1 infects the central nervous system early in the course of infection and neurological complications are common in HIV-1-infected individuals. Approximately 20% of individuals with acquired immunodeficiency syndrome (AIDS) not treated with antiretroviral therapy develop a subcortical dementia, AIDS dementia complex (ADC). LÄS MER
2. HIV-1 infection of the central nervous system. Markers of pathogenesis and antiretroviral treatment effects
Sammanfattning : Human immunodeficiency virus type 1 (HIV-1) invades the central nervous system (CNS) early in the course of infection and either directly or through opportunistic infections causes a spectrum of neurological complications. The most severe manifestation of HIV-1 CNS infection is AIDS Dementia Complex (ADC), which occurs in approximately 20% of untreated patients with AIDS. LÄS MER
3. Development of novel molecular and microfluidics tools for identification and characterization of latent HIV-1 reservoir
Sammanfattning : The existence of latent HIV-1 reservoir (LR) in all HIV-1 infected patients serves as a major obstacle to completely cure HIV-1 infection. However, up to now there is still no available assay that provides an accurate measurement of the reservoir size. LÄS MER
4. Antiretroviral treatment of HIV-1 in the central nervous system
Sammanfattning : HIV-1 invades the central nervous system (CNS) early in the infectious course. It establishes a chronic progressive infection, and triggers an intrathecal immune response. If left untreated, a majority of patients will develop neurological complications, caused by opportunistic pathogens or HIV-1 itself. LÄS MER
5. On HIV-1 latency and viral reservoirs
Sammanfattning : HIV-1 establishes a latent infection that is inaccessible to treatment in cellular and anatomical reservoirs. This thesis concerns several problematic issues of HIV-1 persistence, including ways to measure and monitor both the virus at low viral concentrations and the depletion of the reservoir. LÄS MER