Sökning: "blocking of T cell functions"

Visar resultat 1 - 5 av 21 avhandlingar innehållade orden blocking of T cell functions.

  1. 1. Recognition requirements and regulatory events directing T cell responses

    Författare :Martin Gullberg; Eva-Lotta Larsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; T cell growth factor production; Lyt-2-positive T suppressor cell; Lyt-2-positive cytotoxic T lymphocytes; activation requirements of T lymphocytes; blocking of T cell functions;

    Sammanfattning : The present study has considered cellular and molecular requirements in T cell responses. The central role of T cell growth factors (TCGF) in T cell responses prompted us to study the regulatory events directing TCGF production in lectin stimulated cultures. LÄS MER

  3. 2. Regulation of T cell effector functions in the intestinal mucosa

    Författare :Petra Holmkvist; Slemhinnans immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; T cells; memory; intestine; cytokines; differentiation; IL-18; inflammation; antigen presentation;

    Sammanfattning : T lymphocytes are a critical cellular component of the adaptive immune response. They are generated in the thymus from bone marrow derived progenitors, where they undergo commitment to the T cell lineage and differentiate and mature into naïve CD4+ and CD8+ T cells. LÄS MER

  4. 3. Effects of invasin and YopH of Yersinia pseudotuberculosis on host cell signaling

    Författare :Anna Gustavsson; Maria Fällman; Arnoud Sonnenberg; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; β1-integrin; Yersinia pseudotuberculosis; Invasin; YopH; Cell-Matrix Adhesion; Filopodia; Cell Spreading; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Integrins are a large family of membrane-spanning heterodimeric (αβ) receptors that bind to ligands on other cells or to extracellular matrix (ECM) proteins. These receptors mediate bidirectional signaling over the cell membrane to induce signaling cascades mediating functions as cell adhesion, spreading and migration. LÄS MER

  5. 4. Modulation of natural killer cell and T-cell functions by CD94/NKG2A receptors

    Författare :Cristina Teixeira de Matos; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NK cells; Dendritic cells; Inhibitory receptors; Cytokines; C1394 NKG2A; HLA-E; Inflammation; Chronic arthritis; Tumor cells.;

    Sammanfattning : Natural Killer (NK) cells constitute a subset of lymphocytes capable of cytokine production and/or cellular cytotoxicity. Although NK cells can be activated experimentally by a multitude of agents, the in vivo mechanisms of activation and regulation are not fully elucidated. LÄS MER

  7. 5. Unconventional T cells in colon adenocarcinomas

    Författare :William Rodin; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Unconventional T cells; MAIT cells; γδ T cells; Colorectal cancer; Tumour immunity;

    Sammanfattning : Many factors influence the initiation and growth of tumours. The infiltration and activity of immune cells in the tumour microenvironment are widely recognised as key factors affecting the clinical outcome of cancer. LÄS MER