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Hittade 3 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Ion channel control of phasic insulin secretion

    Författare :Xingjun Jing; Diabetes - öpatofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; phasic insulin secretion; Diabetes; pancreatic β-cells; ClC chloride channel; exocytosis; CaV channel;

    Sammanfattning : Glucose-stimulated insulin secretion exhibits a biphasic pattern. The mechanism underling biphasic insulin secretion is not fully understood, but consensus exists that an elevation in [Ca2+]i is required for both first- and second-phase insulin secretion. LÄS MER

  3. 2. Transport and release of insulin granules during biphasic insulin secretion

    Författare :Rosita Ivarsson; Diabetes - öpatofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fysiologi; Physiology; granule transport; Myosin 5a; Cyclic AMP; NADPH; Motor protein; Insulin secretion; Cytoskeleton;

    Sammanfattning : Glucose-evoked insulin secretion exhibits two phases: The first phase represents exocytosis of insulin granules situated at the plasma membrane, whereas the second phase reflects insulin release from granules continuously recruited to the plasma membrane. This thesis investigates different aspects of phasic insulin secretion, with the specific aims to elucidate the possible contribution of insulin granule transport, as well as to study the influence of the nucleotides cAMP and NADPH to this process. LÄS MER

  4. 3. Pitfalls in β-cell ion imaging with fluorescent indicators and their use for real-time detection of somatostatin secretion

    Författare :Mingyu Yang; Anders Tengholm; Enming Zhang; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; β-cells; cytoplasmic Ca²⁺; cytoplasmic pH; fluorescent indicators; pancreatic islets; R-GECO1; somatostatin; type 2 diabetes; Molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : Fluorescent ion indicators have become indispensable tools in cell physiology. Dye indicators can easily be loaded into most types of cells, while genetically encoded indicators are advantageous in allowing specific cellular or subcellular targeting. LÄS MER