Sökning: "patologi Patologi Molekylär medicin"

Visar resultat 16 - 20 av 71 avhandlingar innehållade orden patologi Patologi Molekylär medicin.

1. 16. Signal Transduction in Malignant Cells – Transformation, Activation and Differentiation

   Författare :Karin Kårehed; Fredrik Öberg; Jan-Ingvar Jönsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular medicine; transformation; PDGF; PI3K; Rho-GTPase; U-937; FcγRI; macrophage; Stat1; PKR; NFκB; ATRA; differentiation; Molekylärmedicin; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; Pathology; Patologi;

   Sammanfattning : All aspects of cell life are regulated by signal transduction mechanisms. This thesis describes the regulatory roles of a few key signal transduction molecules involved in three major biological responses. LÄS MER

3. 17. Single-molecule Detection in situ

   Författare :Chatarina Larsson; Mats Nilsson; Ulf Landegren; Sanjay Tyagi; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular medicine; Molekylär medicin; Molecular Medicine; molekylär medicin genetik och patologi ;

   Sammanfattning : The human body contains a variety of different cell types that share a common genome, but differ in how they use the information encoded therein. Variation in molecular content exists even at the level of individual cells, and to provide deeper insight into complex cellular processes methods that permit analysis of each cell on its own are needed. LÄS MER

4. 18. Cell cycle deregulation in breast cancer subgroups and effects on proliferation, migration and tamoxifen resistance

   Författare :Sophie Lehn; Malmö Molekylär patologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; subgroups; proliferation; migration; stem cells; tamoxifen; estrogen receptor;

   Sammanfattning : Breast cancer is a heterogenous disease which can be divided in subgroups of distinct biology with disparate prognosis and response to treatment. The overall aim of this thesis was to delineate subgroup specific behaviour in breast cancer cells with focus on proliferation, migration and stem-like cell activity. LÄS MER

5. 19. Stem cell function and organ development : analysis of Lhx2 function in hematopoietic stem cells and eye development

   Författare :Lina Dahl; Leif Carlsson; Jan-Ingvar Jönsson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lhx2; hematopoietic system; hematopoietic stem cell; progenitor; embryonic stem cell; embryoid body; eye development; forebrain; eye field transcription factor; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; molekylär medicin genetik och patologi ; molecular medicine  genetics and pathology ;

   Sammanfattning : When a multicellular organism suffers damages to tissues/organs it heals itself by either substituting the lost cellular matrix by scar formation or by regenerating the lost tissue. Regeneration likely occurs by a recapitulation of the developmental process that formed the organ. LÄS MER

7. 20. RNA-based Prognostic Markers in Chronic Lymphocytic Leukemia

   Författare :Marie Sevov; Richard Rosenquist; Mahmoud Mansouri; Denis Alexander; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chronic lymphocytic leukemia; prognostic markers; RNA-based markers; LPL; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; Haematology; Hematologi; Medical Science; Medicinsk vetenskap;

   Sammanfattning : Chronic lymphocytic leukemia (CLL) is a heterogeneous disease where a significant proportion of patients will develop an aggressive disease. Today, the mutational status of the immunoglobulin heavy variable (IGHV) genes is one of the strongest prognostic markers in CLL, where unmutated IGHV genes correlate with poor outcome. LÄS MER