Sökning: "hematopoietic system"
Visar resultat 1 - 5 av 147 avhandlingar innehållade orden hematopoietic system.
1. Stem cell function and organ development : analysis of Lhx2 function in hematopoietic stem cells and eye development
Sammanfattning : When a multicellular organism suffers damages to tissues/organs it heals itself by either substituting the lost cellular matrix by scar formation or by regenerating the lost tissue. Regeneration likely occurs by a recapitulation of the developmental process that formed the organ. LÄS MER
2. Regulation of Hematopoietic Stem Cells
Sammanfattning : This thesis is about the regulation of hematopoietic stem cells (HSCs) that represent rare cells residing in the bone marrow (BM) of adults. They are multipotent cells that have the capacity to differentiate to all mature cells of the blood system and have the capacity to self-renew, i.e. generate new HSCs. LÄS MER
3. Identification of Unique Hematopoietic Stem Cell Properties
Sammanfattning : Hematopoietic stem cells (HSC) are sufficient and required for life long production of all blood cell lineages. Steady state HSCs are largely quiescent and we demonstrate that the kinetics of HSC cell cycling are slower compared to more committed progenitor cells also during expansion and self-renewal ex vivo and in physiological conditions. LÄS MER
4. Primary immunodeficiency in southern Sweden. Strategies for diagnosis and clinical management
Sammanfattning : The overall aim of this PhD project was to gain insight into the incidence of primary immunodeficiency (PID) in southern Sweden and to optimize diagnostic and treatment measures for these patients. We estimated the occurrence rate of PID in the pediatric population of southern Sweden during a period of 4 years and described the demographic, clinical and immunological characteristics of the identified cases. LÄS MER
5. Separation and Further Characterization of Hematopoietic Cell Populations Based on Phenotypic and Biophysical Properties
Sammanfattning : Hematopoietic stem cells (HSC) are multipotent and possess self-renewal capacity. Thus, they can sustain a life-long hematopoiesis and are also capable of restoring the hematopoietic system when transplanted to a patient. LÄS MER