Sökning: "oxidized LDL"

Visar resultat 41 - 45 av 48 avhandlingar innehållade orden oxidized LDL.

1. 41. Studies of atherosclerosis in systemic lupus erythematosus

   Författare :Cristina Anania; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The role of inflammation in the development of atherosclerosis is now accepted and a focus of many studies because of its complex mechanisms. The risk of cardiovascular disease (CVD) and atherosclerosis is reported to be increased in systemic lupus erythematosus (SLE), especially in the group of young women. LÄS MER

3. 42. Novel immunologic cellular mechanisms in atherosclerosis and potential therapeutic implications

   Författare :M Mizanur Rahman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Atherosclerosis, an arterial ailment, is a major cause of cardiovascular diseases (CVD), which cause more than 17 million deaths each year and the number is expected to rise. In recent years atherosclerosis has been shown to be an inflammatory condition involving activated immunocompetent cells, including T-cells, macrophages and dendritic cells (DC), but the mechanism by which these cells are activated remains to be elucidated in detail. LÄS MER

4. 43. Expression of thioredoxin reductase 1 in mammalian cells with regulation by the core promoter and use of alternative splice variants

   Författare :Anna-Klara Rundlöf; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Redox regulation; thioredoxin reductase; TXNRD1; selenoprotein; promoter; transcription; alternative splicing; expression;

   Sammanfattning : Reactive oxygen species are generated in cells as by-products of aerobic metabolism. To protect from damaging effects the cells possess several antioxidant systems and one of the most important is the thioredoxin system. LÄS MER

5. 44. Identification of natural activators of the nuclear receptor peroxisome proliferator-activated receptor : relevance to the pathogenesis of atherosclerosis

   Författare :Jane Wigren; Ernst Oliw; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : Polyunsaturated fatty acids induce peroxisome proliferation. This phenomenon is mediated by the ligand-dependent transcription factor peroxisome proliferator-activated receptor (PPAR). This thesis is an investigation on the role of eicosanoids and oxidized products of linoleic acid for the activation of PPARs. LÄS MER

7. 45. Importance of microenvironment and antigen in the regulation of growth and survival of CLL cells

   Författare :Ann-Charlotte Bergh; Anders Rosén; Richard Rosenquist Brandell; Dimitar Efremov; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Chronic lymphocytic leukemia (CLL) cells rapidly die when put in culture implying that microenvironmental signals delivered by accessory cells confer CLL cells with a growth advantage. Recent findings show that CLL cells are antigen experienced and antigen binding play a critical role in the pathogenesis of the disease. LÄS MER