Sökning: "orphan receptor"

Visar resultat 16 - 20 av 46 avhandlingar innehållade orden orphan receptor.

  1. 16. NR4A orphan nuclear receptors in immediate early regulation of retinoid signaling and neuroprotection

    Författare :Nikolaos Volakakis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : NR4A receptors show distinct properties that make them unique within the family of nuclear receptors. They lack a ligand-binding cavity and a canonical coactivator-binding site and they are induced both in vivo and in vitro in an immediate early way by an extremely wide repertoire of substances/conditions. LÄS MER

  3. 17. Some aspects of nuclear receptor function in the CNS : novel roles of Nurr1 and RXR in developing and mature neurons

    Författare :Åsa Wallén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The nuclear receptor superfamily comprises the receptors for steroid hormones, thyroid hormone, vitamin D and retinoids. The family also includes a number of receptors that lack identified ligands, and are therefore referred to as orphan receptors. LÄS MER

  4. 18. Regulation of cytochrome P4502C7 : effects of growth hormone and vitamin A

    Författare :Stefan Westin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :P450; growth hormone; vitamin A; gene regulation; orphan receptors;

    Sammanfattning : Members of the CYP2C subfamily, highly represented in rat liver, are constitutively expressed genes that encode enzymes that metabolize endogenous substrates such as steroids. Expression of P4502C11 and P4502C12 in rat liver is regulated in a sex-specific manner that ultimately depends on the sexually differentiated secretory pattern of GH release. LÄS MER

  5. 19. On retinoid receptors, Nurr1 and related transcription factors in the CNS

    Författare :Rolf H Zetterström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Nurr1; NGFI-B; Nor1; RAR; RXR; CRBP; CRABP; substantia nigra; basal ganglia; dopamine; orphan receptor; vitamin A; retinoic acid; transcription factor;

    Sammanfattning : It has long been known that retinoids (vitamin A derivatives) are required for normal development and growth; in excess however metabolites such as all-trans retinoic acid are potent teratogens. Retinoids exert their effects through transcription factors known as the retinoic acid receptors (RARam -ß and -y) and retinoid X receptors (RXRa, -ß and -y). LÄS MER

  7. 20. HIV-1 infection during pregnancy and in children : significance of HIV-1 variability and the placental barrier

    Författare :Charlotte Casper; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :biological phenotype; genetic subtype; chemokine receptor; coreceptor; mother- to-child transmission; placenta; disease progression; child; pregnancy;

    Sammanfattning : With the global increase in human immunodeficiency virus 1 (HIV-1) infection in women of childbearing age, there has also been an alarming increase in the number of mother-to-child transmissions of HIV-1. Although antiretroviral therapy and Cesarian section have been demonstrated to significantly decrease the vertical transmission rate of, these interventions are not widely available in the developing world. LÄS MER