Sökning: "oestrogen receptor"

Visar resultat 26 - 30 av 36 avhandlingar innehållade orden oestrogen receptor.

  1. 26. Studies of targeted therapy in breast cancer using trastuzumab : HER2 testing and trastuzumab treatment, clinical and economic evaluation

    Författare :Ulla Wilking; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The incidence in breast cancer has more than tripled in Sweden since the 1960-ies. During the same time period the 5-year survival rate has increase from around 65% to almost 90%. The survival increase is mainly related to medical treatments (endocrine treatments, chemotherapy in different combinations), radiotherapy and breast cancer screening. LÄS MER

  3. 27. Modern Staging in Primary Breast Cancer-aspects of micrometastatic disease in bone marrow and molecular profiles in lymph node metastases

    Författare :Anna-Karin Falck; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer; biomarker expression; lymph node metastases; relapse; molecular subtype classification; disseminated tumour cells; bone marrow; prognosis; mode of detection;

    Sammanfattning : Breast cancer is a heterogeneous disease with variations in the biological profile and subsequent clinical prognosis. Molecular mechanisms for tumour progression are currently being explored in scientific settings, suggesting parallel evolution of tumour cells at primary and metastatic locations. LÄS MER

  4. 28. Cell cycle alterations and 11q13 amplification in breast cancer : prediction of adjuvant treatment response

    Författare :Marie Ahnström Waltersson; Olle Stål; Marie-Louise Fjällskog; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The growth and development of the breast is to a large extent regulated by oestrogens through the oestrogen receptor (ER). Activation of the ERα triggers transcription of genes that are important for cell proliferation and stimulates entry into the G1 phase of the cell cycle. LÄS MER

  5. 29. Aggressive breast cancer : epidemiological studies addressing disease heterogeneity

    Författare :Johanna Holm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Breast cancer is either the number one or the second most common cause of cancer death in women in the world, depending on region¹. It is a cancer heterogeneous in many aspects related to the aggressiveness, such as proliferation rate, metastatic capacity and survival. LÄS MER

  7. 30. Maternal and neonatal anthropometry and growth factor expression and apoptosis in human placenta : a comparison between two populations

    Författare :Shahzad Akram; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and IGFBP proteases, are key endocrine regulators of somatic growth and cellular proliferation. IGFs are involved in growth both pre- and postnatally. LÄS MER