Sökning: "nucleosides"

Visar resultat 21 - 25 av 48 avhandlingar innehållade ordet nucleosides.

  1. 21. Drug-based therapies for auditory trauma

    Författare :Anette Fransson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Deafness is one of the most common health conditions in the developed countries, and worldwide, an estimated 70 million people are deaf. For people with severe to profound hearing loss, a cochlear implant is the only treatment today. The most common forms of severe hearing loss and deafness are related to morphological changes in the cochlea. LÄS MER

  3. 22. Frameshifting as a tool in analysis of transfer RNA modification and translation

    Författare :Ramune Leipuviene; Glenn Björk; Diana Downs; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; minor tRNA; frameshifting; suppression; L9; hopping; tRNA thiolation; [Fe-S] cluster; [Fe-S] protein; TtcA; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Studies of ribosomal reading frame maintenance are often based on frameshift mutation suppression experiments. In this thesis, suppression of a frameshift mutation in Salmonella enterica serovar Typhimurium by a tRNA and a ribosomal protein are described. LÄS MER

  4. 23. Influence of wobble uridine modifications on eukaryotic translation

    Författare :Hasan Tükenmez; Anders Byström; Tracy Nissan; Sebastian Leidel; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Elongator is a conserved six subunit protein (Elp1p-Elp6p) complex that is required for the formation of ncm5 and mcm5 side chains at wobble uridines in transfer RNAs (tRNAs). Moreover, loss-of-function mutations in any gene encoding an Elongator subunit results in translational defects and a multitude of phenotypic effects. LÄS MER

  5. 24. Studies on phosphate ester cleavage and development of oligonucleotide based artificial nucleases (OBAN’s)

    Författare :Hans Åström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Five different Oligonucleotide Based Artificial Nuclease (OBAN) systems have been synthesized. OBAN's may be regarded as a development of traditional antisense methodology where inhibition of gene expression can be achieved by hybridizing a synthetic oligonucleotide to natural mRNA and thus inhibiting further translation into protein products. LÄS MER

  7. 25. Targets and strategies for drug development against human African sleeping sickness

    Författare :Farahnaz Ranjbarian; Anders Hofer; Staffan G. Svärd; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; T. brucei thymidine kinase; T. brucei methylthioadenosine phosphorylase; FANA-A purine nucleoside analogues; essential oils;

    Sammanfattning : Trypanosoma brucei is a causative agent of African sleeping sickness. It is an extracellular parasite which circulates in the blood, lymph and eventually invades the central nervous system. LÄS MER