Sökning: "normal hematopoietic cells"

Visar resultat 11 - 15 av 109 avhandlingar innehållade orden normal hematopoietic cells.

  1. 11. Regulatory mechanisms contributing to the homeostasis of normal and malignant hematopoietic cells

    Författare :Harsha Madapura Sekharappa; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Bone marrow is the site of origin of diverse population of hematological cells with lineage specific function. The different lineages of cells originate from a common progenitor that has a strong self-renewable capability giving rise to myeloid and lymphoid progenitor cells. LÄS MER

  3. 12. Transforming growth factor a in human hematopoietic cells

    Författare :Thomas M. Walz; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : TGF-a, transforming growth factor a, is a potent growth factor belonging to the family of EGF (epidermal growth factor) -related proteins. Binding to the same receptor as EGF it has a ubiquitous repertoire of target cells, including, mesenchymal, epithelial and neuronal cells. LÄS MER

  4. 13. Regulation of normal and cancer cells as a base for cell cycle-targeted therapy

    Författare :Regina Miftakhova; Malmö Experimentell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell cycle regulation; cyclin A1; stem cells; stem cell niche; epigenetics; cancer;

    Sammanfattning : The majority of current treatments used for treatment of prostate cancer (PCa) and leukemia are often limited to a narrow subsets of treated patients. As such, there still remains a significant scope for gaining deeper understanding of molecular mechanisms underlying cancer metastasis for improvement of targeted treatment. LÄS MER

  5. 14. Development of Adenoviral Vectors for Studying Hematopoietic Stem Cell Function

    Författare :Marcus Järås; Institutionen för laboratoriemedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematologi; extracellulära vätskor; extracellular fluids; hTERT; adenovirus; hematopoietic stem cells; Haematology;

    Sammanfattning : Hematopoietic stem cells (HSCs) are defined by their capacity to self-renew and differentiate into all hematopoietic cell lineages. Postnatally, HSCs reside predominantly in the bone marrow and are relatively rare, but important cells because of their therapeutic potential in bone marrow transplantation protocols and in their involvement in the origin of certain leukemias. LÄS MER

  7. 15. Telomerase activity and its regulation in malignant hematopoietic cells

    Författare :Dawei Xu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :hTERT mortalization malignancy activity telomerase regulation;

    Sammanfattning : Telomerase, a multicomponent ribonucleoprotein, synthesizes TTAGGG telomeric repeats essential for the stability and integrity of chromosomes. Most normal human somatic cells exhibit undetectable telomerase activity. LÄS MER