Sökning: "negative affect"

Visar resultat 36 - 40 av 838 avhandlingar innehållade orden negative affect.

  1. 36. Antibiotic resistance in Gram-negative bacilli : with focus on cephalosporin resistance mechanisms in Escherichia coli and Klebsiella pneumoniae

    Författare :Owe Källman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Objectives: The objectives of this thesis were to study mechanisms conferring cefuroxime resistance in clinical non-ESBL (extended-spectrum beta-lactamase) producing isolates of Escherichia coli and Klebsiella pneumoniae, as well as the presence of co-resistance to other antibiotics in the K. pneumoniae isolates. LÄS MER

  3. 37. Clinical significance of immunohistochemistry in breast cancer diagnostics

    Författare :Slavica Janeva; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer biomarkers; immunohistochemistry; surrogate subtype; RT- qPCR; multifocal breast cancer; lymph node metastasis; triple-negative breast cancer; older women;

    Sammanfattning : For patients with breast cancer, modern patient-tailored treatment depends on tumor- specific characteristics, i.e., estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor 2 (HER2), and the proliferation marker Ki67. LÄS MER

  4. 38. The proteasome as a target for cancer therapy

    Författare :Peter Larsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Cell viability assay; Chemotherapy; Drug repurposing; Genomic and transcriptomic signatures; Prognostic biomarkers; Proteasome; Proteasome genes; Proteasome inhibitors; Drug sensitivity biomarkers; Synergistic effect; Triple-negative breast cancer;

    Sammanfattning : The main objective of this PhD thesis was to evaluate the significance of proteasome genes as prognostic markers for different cancer types and identify specific cancer forms that respond to proteasome inhibition. The proteasome (PSM) plays an important role in maintaining cellular proteostasis and degrades the majority of proteins that require breakdown in the cell. LÄS MER

  5. 39. Ethyl glucuronide : a new biochemical marker for acute alcohol intake : studies on possible causes for false-negative or false-positive results

    Författare :Helen Dahl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In recent years, there has been a growing interest in various biochemical markers for detecting acute and chronic alcohol consumption. Biochemical markers for acute and chronic drinking play important roles in detecting alcohol use, abuse and dependence in hospital settings, work place settings, traffic medicine and in forensic toxicology examinations. LÄS MER

  7. 40. On extrinsic and intrinsic organizational themes in gram negative bacteria and their role in evolution and virulence of the bacterial genus Salmonella spp

    Författare :Anders Folkesson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Salmonella; fimbriae; evolution; cell wall; peptidoglycan;

    Sammanfattning : Gram-negative bacteria are composed of intrinsic organizational themes such as outer and inner membrane, cell wall, and replicons. Themes that not only determine the body-plan and physical properties but also set the boundaries for choice of life style and evolution of the organisms. LÄS MER