Sökning: "epigenetic dysregulation"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden epigenetic dysregulation.

  1. 1. Epigenetic dysregulation in relation to psychiatric traits in adolescence and adulthood

    Författare :Adrian Desai Boström; Helgi B. Schiöth; Daniel Nätt; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; methylome-wide; DNA methylation; hypersexual disorder; microRNA; oxytocin signaling; psychiatry; hsa-miR-4456; microRNA-4456; MIR4456; epigenetic dysregulation; microRNA expression; gene target prediction; epigenetics; suicide; suicide attempt; HPA axis; CRH gene; Epigenetics; Methylation; Adolescent depression; MIR4646; methylome-wide association study; Omega-3; mQTL analysis; GAD1; HDAC3; DAWBA;

    Sammanfattning : Epigenetics has evolved into a key research focus in the field of psychiatry. DNA methylation is the most researched epigenetic mechanism. In paper I-III, 130 and 93 adolescents were randomly recruited at two separate intervals. LÄS MER

  2. 2. Genomic and epigenetic investigations of Silver-Russell syndrome and growth restriction

    Författare :Sara Bruce; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : A combination of genes, their epigenetic regulation, and the environment control the phenotypes of an individual, such as how short or tall one grows. Epigenetics refers to chemical modifications of DNA and histones that regulate gene activity and genome stability, and can take the form of, for example, addition of a methyl group to DNA. LÄS MER

  3. 3. Mechanisms of Prodynorphin Gene Dysregulation in the Brain of Human Alcoholics

    Författare :Malik Mumtaz Taqi; Georgy Bakalkin; Fred Nyberg; Hallberg Mathias; Wolfgang.H Sommer; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Sammanfattning : The endogenous opioid system (EOS) including dynorphin opioid peptides and κ-opioid receptor (KOR) plays a critical role in alcohol dependence. Aims of the thesis were to evaluate whether the EOS undergoes molecular adaptations in brain areas involved in cognitive control of addiction in human alcohol dependent subjects, and to analyze the impact of genetic and epigenetic factors on these adaptive changes. LÄS MER

  4. 4. Exploring the role of epigenetic alterations in myeloid malignancies with focus on drug response

    Författare :Hani Abdulkadir Ali; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : The production of blood cells (hematopoiesis), where the hematopoietic stem cell (HSC) is the cell of origin of all blood cells, is regulated by a complex network of intrinsic and extrinsic signals. Dysregulation of hematopoiesis, including somatic heterozygous mutations, cytogenetic aberrations, or epigenetic aberrations, are found in hematological malignancies. LÄS MER

  5. 5. How can an organism´s life experience affect their descendants? Insights from epigenetic and transgenerational effects of chemical exposure in zebrafish

    Författare :Mélanie Blanc; Steffen Keiter; Joëlle Rüegg; Xavier Cousin; Nikolai Scherbak; Michael K. Skinner; Örebro universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Neurotoxicity; behavior; RNA-Seq; RRBS; TEI; permethrin; PCBs; PBDEs; coumarin 47;

    Sammanfattning : Environmental pollution causes approx. 10% of human diseases, and some develop in the progeny because of parental exposure. Effects passed on to subsequent generations may be a consequence of genetic mutations, or of inherited changes in epigenetic patterns. LÄS MER