Sökning: "epigenetic dysregulation"

Visar resultat 1 - 5 av 19 avhandlingar innehållade orden epigenetic dysregulation.

  1. 1. Epigenetic dysregulation in relation to psychiatric traits in adolescence and adulthood

    Författare :Adrian Desai Boström; Helgi B. Schiöth; Daniel Nätt; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; methylome-wide; DNA methylation; hypersexual disorder; microRNA; oxytocin signaling; psychiatry; hsa-miR-4456; microRNA-4456; MIR4456; epigenetic dysregulation; microRNA expression; gene target prediction; epigenetics; suicide; suicide attempt; HPA axis; CRH gene; Epigenetics; Methylation; Adolescent depression; MIR4646; methylome-wide association study; Omega-3; mQTL analysis; GAD1; HDAC3; DAWBA;

    Sammanfattning : Epigenetics has evolved into a key research focus in the field of psychiatry. DNA methylation is the most researched epigenetic mechanism. In paper I-III, 130 and 93 adolescents were randomly recruited at two separate intervals. LÄS MER

  3. 2. Targeting molecular mechanisms for epigenetic silencing in multiple myeloma : Implications for biology and precision medicine

    Författare :Patrick Nylund; Helena Jernberg Wiklund; Antonia Kalushkova Nair; Fredrik Öberg; Toril Holien; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple myeloma; epigenetics; PRC2; lncRNA; metabolomics; miRNA.;

    Sammanfattning : Multiple myeloma (MM) is a heterogeneous haematological cancer where malignant plasma cells clonally expand within the bone marrow. The transcriptional repressor PRC2 and its catalytic subunit EZH2 play a major role in MM, as PRC2 re-targeting results in a MM-specific gene silencing profile. LÄS MER

  4. 3. Studies on genetic and epigenetic regulation of gene expression dynamics

    Författare :Leonard Hartmanis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The information required to build an organism is contained in its genome and the first biochemical process that activates the genetic information stored in DNA is transcription. Cell type specific gene expression shapes cellular functional diversity and dysregulation of transcription is a central tenet of human disease. LÄS MER

  5. 4. Genomic and epigenetic investigations of Silver-Russell syndrome and growth restriction

    Författare :Sara Bruce; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A combination of genes, their epigenetic regulation, and the environment control the phenotypes of an individual, such as how short or tall one grows. Epigenetics refers to chemical modifications of DNA and histones that regulate gene activity and genome stability, and can take the form of, for example, addition of a methyl group to DNA. LÄS MER

  7. 5. Mechanisms of Prodynorphin Gene Dysregulation in the Brain of Human Alcoholics

    Författare :Malik Mumtaz Taqi; Georgy Bakalkin; Fred Nyberg; Hallberg Mathias; Wolfgang.H Sommer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Sammanfattning : The endogenous opioid system (EOS) including dynorphin opioid peptides and κ-opioid receptor (KOR) plays a critical role in alcohol dependence. Aims of the thesis were to evaluate whether the EOS undergoes molecular adaptations in brain areas involved in cognitive control of addiction in human alcohol dependent subjects, and to analyze the impact of genetic and epigenetic factors on these adaptive changes. LÄS MER