Sökning: "multicase families"

Hittade 3 avhandlingar innehållade orden multicase families.

  1. 1. Systemic lupus erythematosus : pathogenesis and genetics with special reference to multicase families

    Författare :Gerður Gröndal; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :SLE; autoimmune disorders; IL- 10; apoptosis; genetics; multicase families.;

    Sammanfattning : Systemic lupus erythematosus (SLE) is a prototype for systemic autoimmune disease. The etiology is largely unknown although valuable knowledge has been accomplished through intensive research in this field in recent years. LÄS MER

  3. 2. The PD-1 pathway and the complement system in systemic lupus erythematosus

    Författare :Helga Kristjánsdóttir; Marta E Alarcón-Riquelme; Kristján Steinsson; Tom W J Huizinga; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; SLE; autoimmune diseases; PD-1; C4AQ0; low MBL; multicase family; Immunology; Immunologi; medicinsk genetik; Medical Genetics;

    Sammanfattning : Autoimmune diseases occur in up to 3-5% of the general population and represent a diverse collection of diseases with regards to clinical manifestations. The unifying factor of autoimmune diseases is tissue and organ damage as a result of an immune response mounted against self-antigens. LÄS MER

  4. 3. Genetic Mapping of Susceptibility Genes for Systemic Lupus Erythematosus

    Författare :Bo Johanneson; Jean Pierre Hugot; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Association analysis; Candidate gene; Complex disease; Genome scan; Linkage analysis; Mapping; Susceptibility genes; Systemic lupus erythematosus; Genetik; Genetics; Genetik; medicinsk genetik; Medical Genetics;

    Sammanfattning : Systemic lupus erythematosus (SLE) is a complex autoimmune disease with unknown etiology. The aim of this thesis was to identify susceptibility regions through genetic mapping, using model-based linkage analysis on nuclear and extended SLE multicase families. LÄS MER