Sökning: "multicase family"

Hittade 2 avhandlingar innehållade orden multicase family.

1. 1. The PD-1 pathway and the complement system in systemic lupus erythematosus

   Författare :Helga Kristjánsdóttir; Marta E Alarcón-Riquelme; Kristján Steinsson; Tom W J Huizinga; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; SLE; autoimmune diseases; PD-1; C4AQ0; low MBL; multicase family; Immunology; Immunologi; medicinsk genetik; Medical Genetics;

   Sammanfattning : Autoimmune diseases occur in up to 3-5% of the general population and represent a diverse collection of diseases with regards to clinical manifestations. The unifying factor of autoimmune diseases is tissue and organ damage as a result of an immune response mounted against self-antigens. LÄS MER

3. 2. Genetic Mapping of Susceptibility Genes for Systemic Lupus Erythematosus

   Författare :Bo Johanneson; Jean Pierre Hugot; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Association analysis; Candidate gene; Complex disease; Genome scan; Linkage analysis; Mapping; Susceptibility genes; Systemic lupus erythematosus; Genetik; Genetics; Genetik; medicinsk genetik; Medical Genetics;

   Sammanfattning : Systemic lupus erythematosus (SLE) is a complex autoimmune disease with unknown etiology. The aim of this thesis was to identify susceptibility regions through genetic mapping, using model-based linkage analysis on nuclear and extended SLE multicase families. LÄS MER