Sökning: "mouse co-culture model"

Visar resultat 1 - 5 av 15 avhandlingar innehållade orden mouse co-culture model.

1. 1. Investigation of tumour/stroma crosstalk in pancreatic cancer by an advanced 3D co-culture model

   Författare :Xinyuan Liu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies all over the world. This dire situation is mainly attributable to the dense desmoplasia in the tumour microenvironment (TME) and almost complete resistance to conventional chemotherapy. LÄS MER

3. 2. Determining the role of guanylate-binding proteins for host defense against Francisella tularensis

   Författare :Nasibeh Mohammadi; Anders Sjöstedt; Wolfgang P. Schröder; Anetta S. Härtlova; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella tularensis; Guanylate-binding proteins; bone marrow-derived macrophages; IFN-γ activation; cytokine patterns; inflammasome pathways; co-infection; mouse co-culture model; Biochemistry; biokemi; immunologi; Immunology; mikrobiologi; Microbiology; molekylärbiologi; Molecular Biology; Infectious Diseases; infektionssjukdomar;

   Sammanfattning : Francisella tularensis is a highly virulent, intracellular bacterium and the causative agent of the human disease tularemia. This is a zoonotic, often vector-borne disease. Due to its intracellular nature, F. LÄS MER

4. 3. The reactive stroma in pancreatic diseases

   Författare :Jessica Norberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Stroma, or activated connective tissue, is a key component in both pancreatitis and pancreatic tumors. Acute pancreatitis (AP) is an inflammation of the pancreas which ranges from mild and local to systemic with severe complications and high mortality. LÄS MER

5. 4. Challenges in Islet Transplantation and Strategies to Improve Beta-Cell Function

   Författare :Hanna Liljebäck; Per-Ola Carlsson; James Shaw; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Islet transplantation; Type 1 diabetes; Mesenchymal stem cells; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : The incidence of type 1 diabetes is increasing worldwide and therapies of islet transplantation and potential cell-based therapies are rapidly evolving. Choosing the optimal site for such therapies is crucial for safety and for obtaining the best possible outcome. LÄS MER

7. 5. FOXP3 and CTLA-4 : how isoforms regulate immunological tolerance

   Författare :Sang Liu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The maintenance of immunological tolerance is vital for preventing the immune system to damage normal tissues and physiological function of the body. CD4+FOXP3+ regulatory T (Treg) cells can suppress immune responses in a dominant manner and are essential for immunological tolerance. LÄS MER