Sökning: "mTOR pathway"

Visar resultat 26 - 30 av 55 avhandlingar innehållade orden mTOR pathway.

  1. 26. Intracellular pathways involved in formation and degradation of prions

    Författare :Elin Allard; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Prions cause invariably fatal neurodegenerative diseases, in which a misfolded host-encoded protein appears to be the main, if not the only, component of the infectious agent. During disease, a normal cellular protein, PrPC, is converted to a disease-related isoform, PrPSc, by a post-translational process that might require auxiliary cellular cofactors. LÄS MER

  3. 27. Cell-autonomous and paracrine mechanisms underlying Pik3ca-driven vascular malformations

    Författare :Milena Petkova; Taija Mäkinen; Ebba Bråkenhielm; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PI3K; PI3KCA; lymphatic malformations; H1047R;

    Sammanfattning : Vascular malformation is a benign overgrowth of blood or lymphatic vessels leading to life-threatening consequences for affected patients. Activating mutations in the TIE2 receptor cause the majority of venous malformations (VMs), while somatic activating mutations in PIK3CA, leading to the overactivation of the PI3K-AKT pathway, cause both VMs and lymphatic malformations (LMs). LÄS MER

  4. 28. GLI1 modulation of the output of hedgehog signaling in human cancer

    Författare :Yumei Diao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The Hedgehog (HH) signaling pathway has critical roles in embryonic development and tumorigenesis. Aberrant activation of HH signaling has been known to be involved in several types of malignant tumors. GLI1 is a transcription factor that acts not only as the terminal effector but also represents a pathway target gene, amplifying the HH signal. LÄS MER

  5. 29. Towards transcriptome-wide studies of mRNA translation in tissues from cancer patients

    Författare :Shuo Liang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Gene expression consists of multiple strictly regulated steps, including transcription, RNA modification, splicing, messenger RNA (mRNA) transport, mRNA degradation, mRNA translation and protein degradation. mRNA translation, the most energy consuming step, plays a critical role in gene expression via global and selective control of protein synthesis. LÄS MER

  7. 30. IGF, PI3K and HIF-2 in Normal and Tumor Development

    Författare :Sofie Mohlin; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; Hypoxia; Insulin-like Growth Factor; PI3K; HIF-2alpha; Cancer; Development;

    Sammanfattning : Cells adapt to oxygen shortage, hypoxia, by inducing a transcriptional shift governed mainly by Hypoxia Inducible Factor (HIF)-1 and HIF-2. In various cancer forms, including neuroblastoma, high expression of HIF-2α correlates with disseminated disease and poor outcome. LÄS MER