Sökning: "mTOR pathway"
Visar resultat 16 - 20 av 55 avhandlingar innehållade orden mTOR pathway.
16. Nutrient and energy sensing in skeletal muscle
Sammanfattning : Nutrient overload and physical inactivity often leads to the development of obesity and type 2 diabetes. Acute over-nutrition can induce insulin resistance, while physical exercise enhances skeletal muscle insulin sensitivity. Like every living cell, skeletal muscle senses nutrient and energy signals and to adjust metabolic flux. LÄS MER
17. To catch a killer : on the mechanisms of interferon alpha induced apoptosis
Sammanfattning : A major clinical problem regarding treatment of malignant tumours is primary or secondary resistance to therapy. Anti-tumour drugs act primarily by induction of apoptosis. However, the knowledge of how various substances induce apoptosis is still incomplete, and so is the reason for the great variation in cellular sensitivity to these drugs. LÄS MER
18. Transcriptional regulation of ribosome biogenesis in skeletal muscle growth
Sammanfattning : Resistance exercise induces skeletal muscle hypertrophy via repeated exercise bouts. The increased muscle protein synthesis together with altered muscle protein degradation contribute to the adaptation of muscle mass. The number of ribosomes dictates the protein synthetic capacity of muscle. LÄS MER
19. Human muscle response to sprint exercise and nutrient supply with focus on factors related to protein metabolism
Sammanfattning : The overall aim of the present thesis was to study the muscular response to repeated bouts of 30-s sprint exercise. This type of exercise gives rise to a profound metabolic perturbation that might counteract an exercise-induced stimulation of muscle protein synthesis. LÄS MER
20. The Role of Mammalian Target of Rapamycin in the Regulation of Amino Acid Transporters in the Human Placenta
Sammanfattning : Abnormal fetal growth, which is associated with both perinatal morbidity as well as metabolic diseases in adulthood, is an important clinical problem affecting as many as 15% of all pregnancies. However, to this date, there is no specific treatment of this condition. LÄS MER