Sökning: "mTOR pathway"
Visar resultat 6 - 10 av 55 avhandlingar innehållade orden mTOR pathway.
6. Oncogenic ALK signaling in neuroblastoma
Sammanfattning : Over the last decade Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase (RTK) has been identified as a translocation partner in diverse cancer types. In tumors, where the full-length ALK RTK itself is mutated, such as neuroblastoma, the picture is less clear regarding ALKs role as an oncogenic driver. LÄS MER
7. Regulation of Renal Hyaluronan in Water Handling : Studies in vivo and in vitro
Sammanfattning : Hyaluronan (HA) is a negatively charged extracellular matrix (ECM) component with water-attracting properties. It is the dominating ECM component in the renal medullary interstitium, where the amount changes in relation to hydration status: it increases during hydration and decreases during dehydration. LÄS MER
8. The Regulation of Growth and Survival in Human Multiple Myeloma Cells by IGF-I Receptor Signaling
Sammanfattning : Multiple myeloma (MM) is an incurable B-cell malignancy mainly localized to the bone marrow. Our aim was to examine the growth- and survival-promoting role of the IGF-IR and its downstream signaling components in MM cells to identify potential targets for therapy. LÄS MER
9. Unlocking the Role Of Orphan Solute Carrier SLC38A10 In Brain Metabolism : The SLC38A10 transporter in nutrient and metabolic regulation
Sammanfattning : Membrane transporters are the primary gatekeepers of cells and regulate the transport of nutrients, metabolites, ions, water, and neurotransmitters into and across the human cells. The solute carrier transporters (SLCs) are the most prominent transporters, comprising 430 members divided into 65 subfamilies. LÄS MER
10. Exploring mTOR-dependent regulation of mRNA translation in cancer
Sammanfattning : Modulation of mRNA translation via the mammalian target of rapamycin (mTOR) pathway is primarily achieved by integrating internal or external signals onto the translation machinery, especially on the rate-limiting initiation step during mRNA translation. Subsets of transcripts are discriminated by structural and/or sequence features, and encode proteins involved in different biological functions. LÄS MER