Sökning: "homology detection"
Visar resultat 11 - 15 av 18 avhandlingar innehållade orden homology detection.
11. Modeling Amyloid Disease in Drosophila melanogaster
Sammanfattning : Amyloid diseases are caused by protein misfolding and aggregation. To date there are 27 known proteins causing amyloid disorders involving brain and peripheral protein deposition. The proteins involved in this mechanism do not share sequence homology, but the amyloid fibrils share biophysical properties and possibly a common pathogenic mechanism. LÄS MER
12. Delineating Ligand-Receptor Interactions and the Design of Subtype Selective Galanin Receptor Ligands
Sammanfattning : We now celebrate that it is 30 years since galanin was first isolated. During these three decades galanin has been identified in numerous tissues and physiological processes, and in an abundant number of species. In the nervous system galanin primarily displays a modulatory role. LÄS MER
13. Tailoring bioinformatics strategies for the characterization of the human microbiome in health and disease
Sammanfattning : The human microbiome is a very active area of research due to its potential to explain health and disease. Advances in high throughput DNA sequencing in the last decade have catalyzed the growth of microbiome research; DNA sequencing allows for a cost-effective method to characterize entire microbial communities directly, including unculturable microbes which were previously difficult to study. LÄS MER
14. Computational Problems in Modeling Evolution and Inferring Gene Families
Sammanfattning : Over the last few decades, phylogenetics has emerged as a very promising field, facilitating a comparative framework to explain the genetic relationships among all the living organisms on earth. These genetic relationships are typically represented by a bifurcating phylogenetic tree — the tree of life. LÄS MER
15. Theoretical Studies of Protein-Ligand Interactions
Sammanfattning : The protein-ligand interaction is an important issue in rational drug design and protein function research. This thesis focuses on the study of protein-ligand interactions using various molecular modeling methods, which are used in combination to predict the binding modes and calculate the binding free energies of several important protein-ligand systems, as summarized below. LÄS MER
