Sökning: "experimental animal model"

Visar resultat 41 - 45 av 316 avhandlingar innehållade orden experimental animal model.

  1. 41. Experimental implant-associated orthopaedic infections

    Författare :Åke Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Osteomyelitis; anaerobic bacteria; implant design and material; bacterial collagen- and fibronectin-binding;

    Sammanfattning : Although indispensable in today's medicine, orthopaedic implants may also cause adverse reactions. A foreign body increases the local susceptibility to colonisation by microorganisms, and hence the risk of infections. These infections are rare, but many result in prolonged or permanent impairment. LÄS MER

  3. 42. Experimental studies on xenograft rejection

    Författare :Guosheng Wu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The use of animal organs and tissues may provide a solution to the severe and worsening shortage of human grafts. The aims of the present experimental studies were to provide a better understanding of the rejection mechanisms and give new clues for prevention of xenorejection, thereby hopefully contributing to the development of clinical xenotransplantation. LÄS MER

  4. 43. Expression of TGF- isoforms, their receptors and related SMAD proteins in brain pathology : Immunohistochemical studies focusing on infarcts, abscesses and malignant gliomas

    Författare :Ahmad Khaled Ata; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; TGF-beta receptor; SMAD; brain; infarct; abscess; glioma; experimental; human; Genetik; Clinical genetics; Klinisk genetik; Genetics; genetik;

    Sammanfattning : This thesis focuses on the immunohistochemical expression of transforming growth factor beta(TGFβ) isoforms, their receptors and TGF-β-related SMAD proteins in brain pathology, chiefly in-farcts. One key question was whether the expressions of these compounds are altered within glial cells, endothelial cells of microvessels and other cell types in the vicinity of infarcts. LÄS MER

  5. 44. A minimally invasive axial blood flow pump : an experimental and clinical study

    Författare :Urban Lönn; Howard Frazier; Linköpings universitet; []
    Nyckelord :Axial blood flow pump; Hemopump; LVAD; Beating heart CABG; MEDICINE; MEDICIN;

    Sammanfattning : The first aim of this thesis was to evaluate a new minimally invasive axial blood flow pump for treatment of patients needing circulatory support after open heart surgery. This system, the Hemopump temporary cardiac assist device, is a very small catheter mounted intracorporeal pump, which is introduced transvalvularly into the left ventricle. LÄS MER

  7. 45. Antithrombotic Effects of Activated Protein C and Heparins in Deep Arterial Injury

    Författare :Karl Malm; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; traumatology; Kirurgi; ortopedi; traumatologi; orthopaedics; Surgery; mutagenesis; protein S; protein C; heparin; bleeding; arterial thrombosis; animal model;

    Sammanfattning : The investigations presented in this thesis have evaluated different strategies to prevent thrombosis in an experimental model of deep arterial injury in rats. Unfractionated heparin (UFH) is often used to prevent thrombosis in microvascular surgery and in other vascular interventions, but a major drawback of UFH is increased bleeding. LÄS MER