Sökning: "dyskinetic"

Visar resultat 11 - 15 av 24 avhandlingar innehållade ordet dyskinetic.

  1. 11. Molecular basis of L-DOPA-induced dyskinesia : studies on striatal signaling

    Författare :Emanuela Santini; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Parkinson s disease (PD) is a neurological disorder characterized by tremor, rigidity and bradykinesia. PD is caused by selective degeneration of the dopaminergic neurons, which originate in the substantia nigra pars compacta (SNc) and project to the striatum. LÄS MER

  3. 12. Striatal pathways in dyskinesia and dystonia

    Författare :Laura Andreoli; Basala gangliernas patofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Striatum; Dystonia; L-DOPA-induced dyskinesia; DREADD; Mouse model; Dopamine; dopamine receptor;

    Sammanfattning : Purposeful and well-coordinated movements depend on the control exerted by dopamine (DA) on the basal ganglia (BG) network. Accordingly, dysfunctions or lesions of the dopaminergic system in the BG can result in an overall poverty and slowness of movement, cardinal features of Parkinson´s disease (PD), or in dyskinesias, exaggerated and involuntary movements resulting from L-DOPA pharmacotherapy. LÄS MER

  4. 13. Dietary antibodies and gluten related seromarkers in children and young adults with cerebral palsy

    Författare :Reidun Stenberg; Jens Schollin; Curt Tysk; Lotta Dahle; Claes Hallert; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cerebral palsy; children; celiac disease; glutensensitivity; brain; transglutaminase 2 and 6; malnutrition; casein; eggwhite laktoglobulin; Medicine; Medicin;

    Sammanfattning : Background & Aims: Cerebral palsy (CP), the most common physical disorder in children that affect motor function, is associated with a low weight and height. Celiac disease (CD), an autoimmune disorder precipitated by ingestion of gluten, is another common chronic disease in children that has a negative impact on growth. LÄS MER

  5. 14. Selectivity of dopamine D1 and D2 receptor agonists – A combined computational approach

    Författare :Marcus Malo; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; dopamine; agonists; GPCRs; pharmacophore modeling; protein structure modeling; agonist selectivity;

    Sammanfattning : Dopamine (DA) is an endogenous neurotransmitter acting in the central nervous system. DA plays a key role in many vital brain functions such as behavior, cognition, motor activity, learning, and reward. Dopamine receptors belong to the rhodopsin like family of G-protein coupled receptors (GPCRs). LÄS MER

  7. 15. Neurodegenerative diseases studied in human brain and rodent models

    Författare :Sandra Gellhaar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Parkinson’s and Alzheimer’s disease are the two most common neurodegenerative diseases world-wide, but are still little understood. Papers in this thesis examine some of the possible pathogenic mechanisms with the help of mouse models and analysis of human post-mortem tissue. LÄS MER