Sökning: "L-DOPA-induced dyskinesia"
Visar resultat 1 - 5 av 25 avhandlingar innehållade orden L-DOPA-induced dyskinesia.
1. Transcriptional dysregulation in L-DOPA-induced dyskinesia
Sammanfattning : This study explores the role of transcriptional regulation important in the development of L-DOPA-induced dyskinesia in a rat model of Parkinson’s disease. In patients with Parkinson’s disease, dyskinesia is one of the most difficult complications of the DA-replacement therapy by L-DOPA. LÄS MER
2. Presynaptic mechanisms in L-DOPA-induced dyskinesia
Sammanfattning : This study has investigated the impact of presynaptic factors on the development of dyskinesia during chronic L-DOPA treatment in a rat model of Parkinson’s disease (PD). The mechanisms causing dyskinesia are not completely understood but have been proposed to involve changes in gene and protein expression in striatal neurons, which are the main target of dopamine (DA) projections from the substantia nigra pars compacta (SNpc). LÄS MER
3. Striatal adaptations in experimental parkinsonism and L-DOPA-induced dyskinesia
Sammanfattning : Parkinson’s disease (PD) is a neurodegenerative disorder, characterized by the loss of dopamine (DA) producing neurons in the substantia nigra pars compacta (SNc), resulting in typical motor symptoms. DA replacement with L-DOPA is the standard therapy for PD. LÄS MER
4. Involvement of non-dopaminergic systems in L-DOPA-induced dyskinsia
Sammanfattning : Parkinson's disease and L-DOPA-induced dyskinesia (LID) does not merely involve the dopamine (DA) system but also include non-dopaminergic systems such as glutamate and serotonin (5-HT). An aberrant glutamate transmission at the corticostriatal synapse, has been linked to LID. LÄS MER
5. Imaging neurochemical changes associated with Parkinson´s disease and L-DOPA-induced dyskinesia using mass spectrometry
Sammanfattning : Parkinson’s disease (PD), caused by a loss of midbrain dopamine neurons, is the second most common neurodegenerative disease worldwide after Alzheimer’s disease. The primary treatment choice for PD is L-DOPA, the precursor for dopamine, which only affects symptoms and does not inhibit disease progression. LÄS MER