Sökning: "drug partitioning"
Visar resultat 16 - 20 av 21 avhandlingar innehållade orden drug partitioning.
16. Intestinal absorption of drugs : The impact of regional permeability, nanoparticles, and absorption-modifying excipients
Sammanfattning : For successful delivery of orally given drug products, the drug compounds must have adequate solubility and permeability in the human gastrointestinal tract. The permeability of a compound is determined by its size and lipophilicity, and is usually evaluated in various pre-clinical models, including rat models. LÄS MER
17. Chromatographic studies of interactions between solutes, lipid bilayers and the glucose transporter Glut1
Sammanfattning : It is advantageous to analyze solute interactions with biological membranes by chromatography on stationary phases that mimic the membrane structures. In the present work, liposomes, proteoliposomes, human red cells and red cell membrane vesicles were immobilized for analyses ofinteractions between solutes (peptides, drugs, inhibitors and glucose), lipid bilayers and theglucose transporter Glut1. LÄS MER
18. New approaches in biomembrane chromatomatography and microchromatographic techniques
Sammanfattning : Development of methods for rendering chromatography more applicable to studies in lifesciences remains an area of active research. In the present work, new methods inbiomembrane chromatography and microchromatographic techniques have been developedand applied successfully to quantitative analysis of biological interactions and separations ofproteins on a micro-scale. LÄS MER
19. GPCRs regulating catecholaminergic cell survival and function : focus on GPR37
Sammanfattning : Dysfunction and dysregulation of catecholaminergic signaling are major causes of many neurological and psychiatric disorders, including Parkinson’s disease (PD), schizophrenia, ADHD and drug addiction. Currently an incomplete understanding of the mechanisms regulating the function and survival of catecholaminergic neurons hinders the development of effective treatments. LÄS MER
20. Computational Modeling of Reaction and Diffusion Processes in Mammalian Cell
Sammanfattning : PAHs are the reactive toxic chemical compounds which are present as environmental pollutants. These reactive compounds not only diffuse through the membranes of the cell but also partition into the membranes. They react with the DNA of the cell giving rise to toxicity and may cause cancer. LÄS MER
